User:Allyreagle/Choose an Article

Article Selection
Please list articles that you're considering for your Wikipedia assignment below. Begin to critique these articles and find relevant sources.

Option 1

 * Article title
 * Maple syrup urine disease


 * Article Evaluation
 * This article is roughly 50% reliable. There is 18 sources which proves that the information in the article isn't sourced from just one author. However, Wikipedia put a notice at the top of the article that additional sources are needed for verification, so clearly the current citations are a good start but not enough. The article is neutrally written, as it does not try to sway the audience one way or the other. This article is part of a WikiProject Medicine which increases the reliability slightly,


 * Sources
 * The sources for this article are Podebrad F, Heil M, Reichert S, Mosandl A, Sewell AC, Böhles H (April 1999). "4,5-dimethyl-3-hydroxy-25H-furanone (sotolone)--the odour of maple syrup urine disease". Journal of Inherited Metabolic Disease. 22 (2): 107–114. doi:10.1023/A:1005433516026. PMID 10234605 .  Ogier de Baulny H, Saudubray JM (2002). "Branched-chain organic acidurias". Semin Neonatol. 7 (1): 65–74. doi:10.1053/siny.2001.0087. PMID 12069539 .  "Maple syrup urine disease". Genetics Home Reference. 4 May 2015.  "NORD - Maple Syrup Urine Disease". Retrieved 13 December 2019.  "OMIM Entry - # 248600 - MAPLE SYRUP URINE DISEASE; MSUD". www.omim.org. Retrieved 2016-11-14.  Strauss, Kevin A.; Puffenberger, Erik G.; Morton, D. Holmes (1993-01-01). Pagon, Roberta A.; Adam, Margaret P.; Ardinger, Holly H.; Wallace, Stephanie E.; Amemiya, Anne; Bean, Lora JH; Bird, Thomas D.; Fong, Chin-To; Mefford, Heather C. (eds.). Maple Syrup Urine Disease. Seattle (WA): University of Washington, Seattle. PMID 20301495 .  Pasquali, Marzia; Longo, Nicola (December 13, 2011). "58. Newborn screening and inborn errors of metabolism". In Burtis, Carl A.; Ashwood, Edward R.; Bruns, David E. (eds.). Tietz Textbook of Clinical Chemistry and Molecular Diagnostics (5th ed.). Elsevier Health Sciences. p. 2062. ISBN 978-1-4160-6164-9 .  "New screening will protect babies from death and disability". screening.nhs.uk.  "MSUD classifications".  "Maple Syrup Urine Disease (MSUD)". Healthline. Retrieved 2016-11-10.  Hallam P, Lilburn M, Lee PJ (2005). "A new protein substitute for adolescents and adults with maple syrup urine disease (MSUD)". J. Inherit. Metab. Dis. 28 (5): 665–672. doi:10.1007/s10545-005-0061-6. PMID 16151896 .  "Maple Syrup Urine Disease (MSUD): Facts & Information". Disabled World. Retrieved 2016-11-10.  Jaworski MA, Severini A, Mansour G, Konrad HM, Slater J, Henning K, Schlaut J, Yoon JW, Pak CY, Maclaren N, et al. (1989). "Genetic conditions among Canadian Mennonites: evidence for a founder effect among the old country (Chortitza) Mennonites". Clin Invest Med. 12 (2): 127–141. PMID 2706837 .  Mary Kugler, R.N. "Maple Syrup Urine Disease". About.com Health.  Puffenberger EG (2003). "Genetic heritage of Old Order Mennonites in southeastern Pennsylvania". Am J Med Genet C Semin Med Genet. 121 (1): 18–31. doi:10.1002/ajmg.c.20003. PMID 12888983 .  "Maple Syrup Urine Disease (MSUD) - Jewish Genetic Disease". Retrieved 18 December 2015.  "MSUD infographic - gene therapy". Retrieved 13 December 2019.  "Brunetti-Pierri, Nicola & Lanpher, Brendan & Erez, Ayelet & Ananieva, Elitsa & Islam, Mohammad & Marini, Juan & Sun, Qin & Yu, Chunli & Hegde, Madhuri & Li, Jun & Wynn, R. & Chuang, David & Hutson, Susan & Lee, Brendan. (2011). Phenylbutyrate therapy for maple syrup urine disease. Human molecular genetics. 20. 631-

Option 2

 * Article title
 * Genetic disorder


 * Article Evaluation
 * This article is closer to 95% reliable. There are many more sources as compared to the last one, with 32 sources. This is also written very factual and scientific. There is no bias found in this article. Lastly, this article is also a WikiProject Medicine project, increasing the reliability. The only thing that had to be edited on the talk page was an edit to a few of the sources citations. This article would be used for my genetic disease because it would fall under the autosomal recessive subtitle. However, because there is so much information there already, it would be difficult to add additional facts as opposed to the article above.


 * Sources
 * "Genetic Disorders". learn.genetics.utah.edu. Retrieved 2019-07-01. Lvovs, D.; Favorova, O.O.; Favorov, A.V. (2012). "A Polygenic Approach to the Study of Polygenic Diseases". Acta Naturae. 4 (3): 59–71. doi:10.32607/20758251-2012-4-3-59-71. ISSN 2075-8251. PMC 3491892. PMID 23150804 .  Reference, Genetics Home. "What are the different ways in which a genetic condition can be inherited?". Genetics Home Reference. Retrieved 2020-01-14.  "OMIM Gene Map Statistics". www.omim.org. Retrieved 2020-01-14.  "Orphanet: About rare diseases". www.orpha.net. Retrieved 2020-01-14.  Kumar, Pankaj; Radhakrishnan, Jolly; Chowdhary, Maksud A.; Giampietro, Philip F. (2001-08-01). "Prevalence and Patterns of Presentation of Genetic Disorders in a Pediatric Emergency Department". Mayo Clinic Proceedings. 76 (8): 777–783. doi:10.4065/76.8.777. ISSN 0025-6196.  Jackson, Maria; Marks, Leah; May, Gerhard H.W.; Wilson, Joanna B. (2018-12-03). "The genetic basis of disease". Essays in Biochemistry. 62 (5): 643–723. doi:10.1042/EBC20170053. ISSN 0071-1365. PMC 6279436. PMID 30509934 . (calculated from "1 in 17" rare disorders and "80%" of rare disorders being genetic)  "Genetics of Cancer". www.medschool.lsuhsc.edu. Retrieved 2020-01-14.  "OMIM Entry #144010 – HYPERCHOLESTEROLEMIA, FAMILIAL, 2; FCHL2". www.omim.org. Retrieved 2019-07-01.  "OMIM Entry #162200 – NEUROFIBROMATOSIS, TYPE I; NF1". www.omim.org. Retrieved 2019-07-01.  Keane MG; Pyeritz RE (May 2008). "Medical management of Marfan syndrome". Circulation. 117 (21): 2802–13. doi:10.1161/CIRCULATIONAHA.107.693523. PMID 18506019 .  Walker FO (2007). "Huntington's disease". Lancet. 369 (9557): 218–28 [221]. doi:10.1016/S0140-6736(07)60111-1. PMID 17240289 .  "OMIM Entry #603903 – SICKLE CELL ANEMIA". www.omim.org. Retrieved 2019-07-01.  Williams T. N.; Obaro S. K. (2011). "Sickle cell disease and malaria morbidity: a tale with two tails". Trends in Parasitology. 27 (7): 315–320. doi:10.1016/j.pt.2011.02.004. PMID 21429801 .  Kuliev, Anver; Verlinsky, Yury (2005). "Preimplantation diagnosis: A realistic option for assisted reproduction and genetic practice". Curr. Opin. Obstet. Gynecol. 17 (2): 179–83. doi:10.1097/01.gco.0000162189.76349.c5. PMID 15758612 .  Simcikova D, Heneberg P (December 2019). "Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases". Scientific Reports. 9 (1): 18577. doi:10.1038/s41598-019-54976-4. PMC 6901466. PMID 31819097 .  Griffiths, Anthony J.F.; Wessler, Susan R.; Carroll, Sean B.; Doebley, John (2012). "2: Single-Gene Inheritance". Introduction to Genetic Analysis (10th ed.). New York: W.H. Freeman and Company. p. 57. ISBN 978-1-4292-2943-2 .  Griffiths, Anthony J.F.; Wessler, Susan R.; Carroll, Sean B.; Doebley, John (2012). Introduction to Genetic Analysis (10th ed.). New York: W.H. Freeman and Company. p. 58. ISBN 978-1-4292-2943-2 .  "Inheritance Patterns for Single Gene Disorders". learn.genetics.utah.edu. Retrieved 2019-07-01.  Wade, Nicholas (January 29, 2006). "Japanese Scientists Identify Ear Wax Gene". New York Times.  Yoshiura K; Kinoshita A; Ishida T; et al. (March 2006). "A SNP in the ABCC11 gene is the determinant of human earwax type". Nat. Genet. 38 (3): 324–30. doi:10.1038/ng1733. PMID 16444273 .  Mitton, Jeffery B (2002). "Heterozygous Advantage". eLS. doi:10.1038/npg.els.0001760. ISBN 0470016175 .  Poolman EM, Galvani AP (February 2007). "Evaluating candidate agents of selective pressure for cystic fibrosis". Journal of the Royal Society, Interface. 4 (12): 91–8. doi:10.1098/rsif.2006.0154. PMC 2358959. PMID 17015291 .  Allison AC (October 2009). "Genetic control of resistance to human malaria". Current Opinion in Immunology. 21 (5): 499–505. doi:10.1016/j.coi.2009.04.001. PMID 19442502 .  Woolf, LI (1986). "The heterozygote advantage in phenylketonuria". American Journal of Human Genetics. 38 (5): 773–5. PMC 1684820. PMID 3717163 .  Weatherall, D. J. (2015). "The Thalassemias: Disorders of Globin Synthesis". Williams Hematology (9e ed.). McGraw Hill Professional. p. 725. ISBN 9780071833011 .  Robert, Nussbaum; McInnes, Roderick; Willard, Huntington (2007). Thompson & Thompson Genetics in Medicine. Philadelphia PA: Saunders. pp. 144, 145, 146. ISBN 9781416030805 .  Milunsky, Aubrey, ed. (2004). Genetic disorders and the fetus : diagnosis, prevention, and treatment (5th ed.). Baltimore: Johns Hopkins University Press. ISBN 978-0801879289 .  "Diagnostic Tests – Amniocentesis". Harvard Medical School. Archived from the original on 2008-05-16. Retrieved 2008-07-15.  Ginn, Samantha L.; Alexander, Ian E.; Edelstein, Michael L.; Abedi, Mohammad R.; Wixon, Jo (February 2013). "Gene therapy clinical trials worldwide to 2012 – an update". The Journal of Gene Medicine. 15 (2): 65–77. doi:10.1002/jgm.2698. PMID 23355455 .  Verma, I. M. (22 August 2013). "Gene Therapy That Works". Science. 341 (6148): 853–855. Bibcode:2013Sci...341..853V. doi:10.1126/science.1242551. PMID 23970689 .  "A probable genetic origin for pitting enamel hypoplasia on the molars of Paranthropus robustus". ResearchGate. Retrieved 2019-03-09.

Option 3

 * Article title
 * BCKDHA


 * Article Evaluation
 * This article is similar to the first in the sense that there are not many sources that back up the material posted. Currently there are only 11 sources, which is one of the main reasons that Wikipedia has graded this article on the level Stub, which is defined as "articles that are either very short or rough collections of information that will need much work" on the quality report. This article is still unbiased but it doesn't have enough information as it is. This is one of the genes that can lead to the Maple Syrup Urine Disease
 * Sources
 * GRCh38: Ensembl release 89: ENSG00000248098 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000060376 - Ensembl, May 2017  "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.  "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.  "Entrez Gene: BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide".  "MTSU -- Ezproxy Login". eds.a.ebscohost.com.ezproxy.mtsu.edu. Retrieved 2018-11-18.  Reference, Genetics Home. "BCKDHA gene". Genetics Home Reference. Retrieved 2018-11-14.  Reference, Genetics Home. "BCKDHA gene". Genetics Home Reference. Retrieved 2018-11-15.  "BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide". NCBI. Retrieved 12 April 2019.  Database, GeneCards Human Gene. "BCKDHA Gene - GeneCards | ODBA Protein | ODBA Antibody". www.genecards.org. Retrieved 2018-11-14.  Database, GeneCards Human Gene. "BCKDHA Gene - GeneCards | ODBA Protein | ODBA Antibody". www.genecards.org. Retrieved 2018-11-15.

Option 4

 * Article title
 * BCKDHB


 * Article Evaluation
 * This article discusses another genetic strand that the mutation can occur on.This article is very short and lacks much information that would make it crucial. There are only 5 sources listed and it is ranked on the same Stub quality level as above. However, this article does list many further reading links in order to educate yourself further meaning the authors have done some of their research.
 * Sources
 * GRCh38: Ensembl release 89: ENSG00000083123 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000032263 - Ensembl, May 2017  "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.  "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.  "Entrez Gene: BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease)".

Option 5

 * Article title
 * Human genetics


 * Article Evaluation
 * This article is about 75% reliable. All the information in the article link seems factually based with citations to back them up and unbiased. However, in the Talk page, many fellow wikipedia editors believe that this article lacks detailed descriptions of the genetic processes and skims over important information.


 * Sources
 * Nussbaum, Robert L.; McInnes, Roderick R.; Willard, Huntington F. (2007). Genetics in Medicine (7th ed.). Philadelphia: Saunders. "Glossary". Genetics Home Reference. U.S. National Library of Medicine < http://ghr.nlm.nih.gov/ >. 14 March 2008. External link in |publisher= (help); Missing or empty |url= (help)  Freeman, Scott; Jon C., Herron (2007). "Evolutionary Analysis" (4th ed.). Upper Saddle River: Pearson:Prentice Hall. Missing or empty |url= (help)  Ahn, J.; Lee, J. (2008). "X Chromosome Inactivation". SciTable. Nature Education.  Calkins, Hugh. "Can Sinus Bradycardia Be Inherited?". NEJM Journal Watch. Massachusetts Medical Society.  Campbell, Neil; Reece, Jane (2005). Biology. San Francisco: Benjamin Cummings. p. 265. ISBN 0-07-366175-9 .  McKusick, Victor A. (10 February 2009). "Widow's Peak". Online Mendelian Inheritance in Man. Johns Hopkins University. 194000. Archived from the original on 9 December 2015.  "Genetics/Reproduction". ScienceNet – Life Science. Singapore Science Centre. Archived from the original on 2003-09-25.  McKusick, Victor A. (25 June 1994). "Dimples, Facial". Online Mendelian Inheritance in Man. Johns Hopkins University. 126100. Archived from the original on 9 April 2019.  Wooding, Stephen (28 June 2004). "Natural selection at work in genetic variation to taste". Medical News Today. Archived from the original on 2007-12-13.  Cruz-Gonzalez, L.; Lisker, R. (1982). "Inheritance of ear wax types, ear lobe attachment and tongue rolling ability". Acta Anthropogenet. 6 (4): 247–54. PMID 7187238 .  McKusick, Victor A.; Lopez, A (30 July 2010). "Earlobe Attachment, Attached vs. Unattached". Online Mendelian Inheritance in Man. Johns Hopkins University. 128900.[permanent dead link]  McDonald, John H. (8 December 2011). "Hair Whorl". Myths of Human Genetics. University of Delaware.  McKusick, Victor A. (23 March 2013). "Cleft Chin". Online Mendelian Inheritance in Man. Johns Hopkins University. 119000. Archived from the original on 29 April 2017.  Xue-Jun Zhang; et al. (2004). "A Gene for Freckles Maps to Chromosome 4q32–q34". Journal of Investigative Dermatology. 122 (2): 286–290. doi:10.1046/j.0022-202x.2004.22244.x. PMID 15009706 .  McKusick, Victor A.; O'Neill, Marla J. F. (22 November 2010). "Apocrine Gland Secretion, Variation in". Online Mendelian Inheritance in Man. Johns Hopkins University. 117800. Archived from the original on 30 April 2017.  "Mendelian Traits in Humans" (PDF). Human Genetics. San Diego Supercomputer Center (SDSC).  Chen, Harold (2019-03-08). Buehler, Bruce (ed.). "Genetics of Marfan Syndrome". Medscape. WebMD LLC.  Stafford, Kate; Mannor, Michael. "Mutations and Genetic Disease". Genetic Diseases. ThinkQuest. Archived from the original on 2007-01-03.  "Autosomal Recessive: Cystic Fibrosis, Sickle Cell Anemia, Tay Sachs Disease". Medical Genetics. Children's Hospital of Pittsburgh. 3 February 2008. Archived from the original on 24 August 2009. Retrieved 28 September 2011.  Schrock, Karen (10 January 2008). "Looking at the Sun Can Trigger a Sneeze". Scientific American. Archived from the original on 2011-03-19.  "Inherited Human Traits". EdQuest. Archived from the original on 2012-02-01.  Scott, C. I. (1971). "Unusual facies, joint hypermobility, genital anomaly and short stature: A new dysmorphic syndrome". Birth Defects Original Article Series. 7 (6): 240–246. PMID 5173168 .  Fankhauser, D. B. (2 Feb 2006). "Human Heritable Traits". University of Cincinnati Clermont College. Archived from the original on 2012-02-23.  Tüzün, Yalçın; Karaku, Özge (2009). "Leukonychia" (PDF). Journal of the Turkish Academy of Dermatology. JTAD.  "Learning About Trimethylaminuria". genome.gov. National Human Genome Research Institute.  Kaufmann, Horacio; et al. (April 2003). "Primary hyperhidrosis – Evidence for autosomal dominant inheritance" (PDF). Clinical Autonomic Research (13): 96–98. doi:10.1007/s10286-003-0082-x.  Bowen, R. (25 April 2009). "Lactose Intolerance (Lactase Non-Persistence)". Colorado State University.  Jablecki, Donna Mae. "Variations on a Human Face" (PDF). Science Experiments on File. Facts on File.  Strickland, Barbara. "Acne is a Four Letter Word". Sage Advice. Barbara Strickland. Archived from the original on 2006-02-07.  "Down Syndrome". Mosby's Dictionary of Medicine, Nursing & Health Professions. Elsevier Health Sciences. Retrieved 27 September 2013.  "Cri Du Chat Syndrome (Cat Cry Syndrome)". Encyclopedia of Special Education. Wiley. Retrieved 27 September 2013.  "Klinefelter Syndrome". Encyclopedia of Special Education. Wiley. Retrieved 27 September 2013.  Tager-Flusberg, Helen (1999). Neurodevelopmental Disorders. Massachusetts: Massachusetts Institute of Technology. p. 227. ISBN 0-262-20116-X .  "Etiology". Encyclopedia of Special Education. Wiley. Retrieved 27 September 2013.