User:Alshroufa/Molecular genetics/Bibliography

You will be compiling your bibliography and creating an outline of the changes you will make in this sandbox.

Methods in molecular biology and genetics: looking to the future https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980850/

Developmental genetics with model organisms

https://www.pnas.org/doi/full/10.1073/pnas.2122148119

Zebrafish as a Developmental Model Organism for Pediatric Research https://www.nature.com/articles/pr2008227

Genome editing: A perspective on the application of CRISPR/Cas9 to study human diseases (Review)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414166/

Moving forward with forward genetics: A summary of the INFRAFRONTIER Forward Genetics Panel Discussion

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634052/

Reverse genetics in eukaryotes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017359/

Classic Mendelian Genetics (Patterns of Inheritance)

https://www.ncbi.nlm.nih.gov/books/NBK132145/

Outline of proposed changes
Goal: to expand and improve upon provided information in the article

Molecular genetics is a large area of study, and this article is very limitied in the information it provides. My goal is to initially begin by expanding on some key concepts mentioned such as forward and reverse genetics. I will also include a more extensive history of molecular genetics making sure to touch on mendallian genetics and Morgan Taylor drosophilia experiments that show the concept of chromosomal inheritance. From there I will highlight different ways to conduct screenings, recombinant frequencies etc. I will also include more up to date techniques such as crispr technology that has evolved the way we can conduct genetic testing.

Section- History: (more thorough history of genetics)

Molecular genetics answers questions left behind by classical genetics/mendallian genetics

Molecular genetics aims to answer things like what is a gene? Breakthroughs in DNA research came different researchers. Chemist Johann Friedrich Miescher https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268995/ who was researching white blood cells, discovered a molecule that he named nuclein, which would ultimately be the first discovery of the molecule DNA was later determined to be the molecular basis of life. Biochemist Albrecht Kosell continued to build on that by isolating the basic building blocks of DNA and RNA; made up of the nucleotides: adenine, gunaine, thymine, cytosine. and uracil. In the early 1900's, gregor Mendal made great contibutions to the field of genetics through his various experiments with pea plants and drosophilia flies where he was able to discover some basic principles of inheritcance such as recessive and dominant traits. Anatomist Walther Flemming, discovered what we now know as chromsomes and the process they undergo through mitosis. https://pubmed.ncbi.nlm.nih.gov/11413469/ Him and Theodor Boveri first came up with the chromosomal theory of inheritance, which helped explain some of the patterns Gregor mendel had observed much earlier. In 1953 Francis Crick and James Watson https://www.nature.com/articles/171737a0 who derived the structure of DNA.