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Adrenal Steroids such as glucocorticoids and mineralocorticoids are commonly used as treatments in diseases such as Cogenital adrenal hyperplasia. CAH commonly causes overproduction of androgens, glucocorticoid treatment is used to reduce Adrenocorticotropic hormone (ACTH) and reduce the production of androgens allowing for symptoms of CAH to be managed though treatment is required to be continued regularly for life or symptoms may return.

Glucocorticoids are known to cause suppression of osteoblastic activity causing reduction in bone formation during development and cause an increased amount of bone resorption causing the breaking down of bone tissue. This commonly leads to diseases such as Osteopenia and Osteoporosis in developing humans due to reduced bone mineral density and bone volume density. However studies have shown that glucocorticoid treatment of patients that have CAH does not have major detrimental effects to bone mineral density even showing that BMD was higher in CAH patients that have undergone glucocorticoid treatment. Not much is known however about the precise mechanisms that cause glucocorticoid bone reduction

Adrenal androgens are another form of Adrenal steroids that include dehydroepiandrosterone, androstenedione, androstenediol etc. These androgens have little androgenic activity when compared to other steroids of the same name however they are most commonly converted to other androgens such as testosterone and estrogen, however the most common conversion is into estrogen making andrenal androgens very important in a developing human female.

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