User:Amdavies/sandbox

Overview of Current Article

 * States what CPEB is and what it does
 * Protein that binds RNA to elongate the polyadenine tail, which commonly promotes translation in the cytosol.
 * Where CPEB was first found
 * CPEB's functions in organisms, such as oogenesis, spermatogenesis and memory (neurons)
 * CPEB's role as a mRNA regulator
 * Proteins that CPEB is known to interact with

Proposed Edit to CPEB
I plan on expanding on the functions of CPEB, as well as adding information on CPEB's specific role in oogenesis and spermatogenesis. I would also like to add information about the different types of CPEB proteins and the mechanism of CPEB proteins in promoting translation.

Possible Headers for New Sections

 * Structure of CPEB proteins
 * Mechanism of CPEB proteins
 * Role in Oogenesis
 * Role in Spermatogenesis

Mechanism of CPEB Proteins
CPEB proteins are sequence specific and bind the cytoplasmic polyadenylation element, or CPE, in the 3' UTR of mRNA. They most commonly recognise the CPE sequence UUUUAU, though there are other variations that they recognise. Binding of CPEB proteins and CPSF to the CPE occurs in the nucleus, and then they are exported into the cytosol. While in the cytoplasm, the RNA-protein complex associates with more proteins that shorten the poly(A) tail. At this time, CPEB is bound by the proteins ePAB and Maskin associated with EIF4E, which masks the mRNA and prevents translation.