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= DEMAR3 = DEMAR3 (Hangul: 디마르3) is a South Korean cosmetic brand operated by Natural Substances Lab, a research institute in South Korea. Since the brand was established by a chemical research team, DEMAR3 is known to have a scientific theme. They develop and promote their products with information and data obtained from academic conferences and a variety of biochemical studies and in-house experimentations..

History
DEMAR3 was founded in 2017 by a cosmetic research institute, Natural Substances Lab, previously known as Pure Origin research lab. The lab manufactures cosmetic products, conducts research on both raw materials and cosmetics materials, and produces analytic footage and videos. They made their first academic appearance by participating in the editorial valuation for a research journal, Effect of hydrous and saline stress on seeds of Chamaerops humilis L. at the stage of germination(2016) published by PhytoChem & BioSub journal.

Since the launch of the brand, DEMAR3, has been relatively well-received in the South Korean cosmetic market for accomplishing cumulative net sales of 12 billion after two years from its establishment. Each new product they released was sold out three times in a row. DEMAR3 established a partnership with other pharmaceutical and beauty manufacturers, such as HnG Cosmetics and Incospharm, and a research company, Kolmar Korea, to create their recent products.

Products and Research
Each product of DEMAR3 allegedly came out as a result of published dermatology, biology, chemical research projects or in-house research.

Estud Protector 3.2
Estud Protector 3.2, previously spelled as “protecter”, is a whitening and anti-wrinkle product recognized and certified by the Ministry of Food and Drug Safety (MFDS) in Korea. The product was said to be inspired by the concept of skin regenerating collagen from an academic journal, Decreased Collagen Production in Chronologically Aged Skin, published in 2006. The journal discusses the fact that skin regenerating collagen started to decrease considerably throughout the aging process. Ms. Joe, Assistant Manager from the lab, said their approach was to overcome the damages that occurred by UV rays using functional cosmetics boosting the natural recovery effect.

Re:9 Tuner
RE:9 Tuner is a makeup fixer product unveiled in early 2019 at a release conference in France. The product is said to be using Michell structures to breakdown caked up layers of makeup and moisturizes the skin from inside with silk amino acid to help customers when they fix their makeup.

REM-ROSE 25
REM-ROSE 25 products are wrinkle-care products launched in 2019. The three products of REM-ROSE 25 series; REM-ROSE 25 Shield Crème, REM-ROSE 25 Burning Effector Type 1 and 2, were allegedly inspired by Digestive Activity of Lysosomes, a paper written by a Belgian scientist Christian de Duve and J. W. Coffey, and Ohsumi Yoshinori’s discovery on mechanisms for autophagy which gave him a Nobel prize. The lab and Incospharm insist they succeeded in producing skin-care ingredients with autophagia properties and eleven ingredients effective in targeting wrinkles.

Cita Du Project
Cita Du Project was launched in 2019. It includes six products; Cita Du Aqua Sun Serum, Cita Du Shield Cream, Cita Du Reacting Toner, Cita Du 49 Gel Cleanser, Cita Du 1.6 Burning Type 1, and 2. The series of products are said to be based on an article, Lipid Mediators in Acne, by Monica Ottaviani as the very first case of commercialization of the related studies. Natural Substances Lab publicly recruited volunteers for the research to collect data of superior and inferior skin cells, and the open call caused temporary network congestion on their website. The research found a large amount of Kellis factors in 17% of healthy skin. However, extremely small amounts of Kellis factors were found in acne-prone skin, causing various skin problems. Natural Substances lab announced that there was a significant improvement in acne-prone skin types, such as sebum reduction and purified skin pores when Cita Du products with Kellis factors were applied to participants’ skin.

Technological partnership
National Substances Lab developed technological alliances with several cosmetic manufacturers. REM-ROSE 25 series was co-manufactured by Incospharm, and for the release of Estud Protector 3.2, Kolmar Korea, a research company, and HnG, a manufacturing company, partnered with Natural Substances Lab.