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The Hospice was set up by Elsie Inglis and Jessie MacLaren MacGregor in 1901, and was sited at 219 High Street, Edinburgh

In November 1899, the Medical Women's Club led by Elsie Inglis opened a seven bed hospital, known as the George Square Nursing Home, at 11 George Square.

In 1904 the Home moved to 219 High Street and was renamed the Hospice: its main aim was to provide assistance to the poorer women of Edinburgh during pregnancy and confinement. In 1910 this Hospice amalgamated with the Bruntsfield Hospital, with whom it had shared cooperation between staff for a number of years. While the Bruntsfield catered for medical, surgical and gynaecological work, the Hospice carried out obstetrics and infant work. Both institutions carried on their own dispensaries and retained their own names.