User:Amsmiley16/sandbox

Mary-Claire King Possible Additions

 * I might could add a little bit to her biography section about growing up
 * The talk-page suggests adding a section on an upcoming movie - "Decoding Annie Parker" that is based on Mary-Claire King's work. I can work to depict what is fact and fiction from this movie and write about that
 * a lot of topics she does research and works on are brought up in her page, but not a lot about them. I can do some research into these topics and add more information about her specific contributions

I agree with adding more to her family section and growing up. I also found a few words that maybe could be defined for clarity in the article for the average reader. Comparative protein analysis, epidemiology, and hereditary could all be defined to help readers understand. You could also add more current information on the Human Genome Diversity Project and where it is today. I think adding information on the movie would be a great idea!

Mary-Claire King Additions
These two genes, BRCA 1 and BRCA 2 work together to clean up cells in the body that have been harmed by things such as tobacco or just help clean the cells because they have aged. When these genes do not perform these functions, it causes cells to grow and divide quickly, leading to some types of cancers.

Mary-Clarie King also worked on a project studying the mutations of genes linked to breast cancer inheritance in Nigerian women. King's team decided to do this research on the grounds that more people die in Nigeria from triple negative breast cancer that is diagnosed at a later stage than other, more educated regions of the world, such as Europe or America. At the finish of this study, King's team was still unsure of the reason for such high levels of Triple-negative breast cancer, since many of the people diagnosed were not showing mutations in the BRCA 1 gene. Her study supported the idea that genomic sequencing could be useful as a tool to help detect gene mutations early and be proactive in letting those who have high risks for breast cancer know ahead of time.

Zheng, Y., Walsh, T., Gulsuner, S., Casadei, S., Lee, M. K., Ogundiran, T. O., Ademola, A., Falusi, A. G., Adebamowo, C. A., Oluwasola, A. O., Adeoye, A., Odetunde, A., Babalola, C. P., Ojengbede, O. A., Odedina, S., Anetor, I., Wang, S., Huo, D., Yoshimatsu, T. F., Zhang, J., Felix, G., King, M. C., … Olopade, O. I. (2018). Inherited Breast Cancer in Nigerian Women. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 36(28), 2820-2825.

Decoding Annie Parker: A movie titled Decoding Annie Parker was released in 2013 that depicts the quest of King to discover how genetics could be a cause of beast cancer. In the movie, Helen Hunt portrays Mary-Claire King and Annie Parker is played by Samantha Morton. The movie focuses on Annie and her trials to get King's help. Both Annie's mother and sister were diagnosed with breast cancer and Annie feels that the same could be in her future. Annie gets breast cancer a total of three times, fighting it off each time.