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Bufothionine's Medicinal Prospects in Oncology Practices
Bufothionine has been shown to suppress cell cycle growth of cancerous liver cells. Experiments were conducted in which cultured cancer cells were shown to have an increase in G2-M damage checkpoint, ensuring that growth of the cell will not continue until the damage to the DNA is corrected while also showing a drop in the G0 and G1 activity, which pertains to phase where there is cell growth and RNA production. Similarly, Buifothionine has also been shown to increase the chances of cell death and decrease cell growth of gastric cancer related cells by inhibiting the PIM3 gene, which, in cancerous cells, increases the resistance of chemotherapeutic treatment.