User:AndersonKM/sandbox

1.	Classification (4, 7) 2.	Function a.	Metabolism (7) b.	Hormone Signaling (4, 7, 8) c.	Cell Proliferation (6) 3.	Diagnostic Use a.	Cancer i.	Biomarker (1, 3, 6) ii. PET Scan (2, 3) 4.	Therapeutic Use a.	Neuropsychiatric (2, 5, 8) b.	Cancer (1, 2, 3, 6, 7, 9)

References: 1. van Waarde, A., Rybczynska, A.A., et al. “Sigma Receptors in Oncology: Therapeutic and Diagnostic Applications of Sigma Ligands”

2. Hashimoto, K., Ishiwata, K. “Sigma Receptor Ligands: Possible Application as Therapeutic Drugs and as Radiopharmaceuticals”

3. van Waarde, A., Rybczynska, A.A., et al. “Potential applications for sigma receptor ligands in cancer diagnosis and therapy”

4. Narayana, S., Bhat, R., et al. “Early Development of Sigma-Receptor Ligands”.

5. Skuza, G. “Potential Antidepressant Activity of Sigma Ligands”

6. Huang, Y., Lu, H., et al. “Sigma-2 Receptor Ligands and Their Perspectives in Cancer Diagnosis and Therapy.”

7. Ahmed, I.S.A., Chamberlain, C., Craven, R.J., “S2RPgrmc1: the cytochrome-related sigma-2 receptor that regulates lipid and drug metabolism and hormone signaling”

8. Skuza, G. “Pharmacology of Sigma Receptor Ligand from a Behavioral Perspective”

9. Damaskos, C., Karatzas, T., et al. “Nuclear Receptors in Pancreatic Tumor Cells”