User:Andrea Trementozzi/Nanoparticles and Brain Drug Delivery

Nanoparticles for Drug Delivery to the Brain provides an innovative and promising method for crossing the Blood Brain Barrier and delivering pharmaceuticals to the brain for therapeutic treatment of neurological disorders. Antibiotics, antineoplastic agents, and a variety of central nervous system (CNS)-active drugs, particularly neuropeptides, include many of the molecules that cannot pass this barrier alone. The Blood Brain Barrier (BBB) alone, however, is the not the only physiological barrier for drug delivery to the brain, other factors influence how drugs are transported throughout the body and how they target specific locations for action. Some of these pathophysiological factors include blood flow alterations, edema and increased intracranial pressure, metabolic perturbations, and altered gene expression and protein synthesis.