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Wallis, D. and Muenke, M. (2000), Mutations in holoprosencephaly. Hum. Mutat., 16: 99-108. https://doi.org/10.1002/1098-1004(200008)16:2 <99::AID-HUMU2>3.0.CO;2-0


 * Genetic Mutations involved in holoprosencephaly, government sponsored research.

Embryonic Development
In Holoprosencephaly, the neural tube fails to segment, resulting in incomplete separation of the procencephalon at the fifth week of gestation.

Holoprocencephaly
Holoprocencephaly is common birth defect that occurs in 1 of every 8000 live births.