User:Aneri10699/Evaluate an Article

Which article are you evaluating?
I am evaluating the Ribosomal DNA article.

Why you have chosen this article to evaluate?
This article made me familiar with the ribosomal DNA, it's sequencing, transcription and clinical significance. As at any point there can be mutation in the rDNA and it can cause neurological disorders, so to over come this situation new and different approaches are needed to be think of. That's what made me select the article and study the processes happening in the rDNA.

Evaluate the article
Ribosomal DNA codes for ribosomal RNA (rRNA). Mutation can occur at any point in the transcription process and may alter the protein sequence/ formation. The composition of rRNA is different in eukaryotes and prokaryotes. During the process of transcription, in Drosophila there is continuous change in the sequence which causes the mutation to occur. As being smaller unit of the process of transcription the mutation can occur at lower level as the rDNA sequences are highly conserved in the genome, and after all this if the mutation occurs then we need to find the solution for this situation as it causes the difference in the protein formation. Bloom syndrome is one of the example of this mutation, which occurs when number of tandem repeats increases to hundred folds. To over come this situation gene therapy, can be given to the patient if detected at early stage or even to the developing baby if it found in that stage.