User:Anthonyhcole/Sertraline

The current section reads:"According to several double-blind studies, sertraline is effective in alleviating the symptoms of PMDD, a severe form of premenstrual syndrome. Significant improvement was observed in 50–60% of cases treated with sertraline vs. 20–30% of cases on placebo. The improvement began during the first week of treatment, and in addition to mood, irritability, and anxiety, improvement was reflected in better family functioning, social activity and general quality of life. Work functioning and physical symptoms, such as swelling, bloating and breast tenderness, were less responsive to sertraline.[3][1][2] Despite the well-known sexual side effects of sertraline, significantly higher improvement of sexual functioning was achieved by the sertraline group as compared to the placebo group.[4] A three-way comparison of sertraline, norepinephrine reuptake inhibitor tricyclic antidepressant desipramine, and placebo demonstrated the superiority of sertraline, while desipramine fared no better than placebo.[5] Taking sertraline only during the luteal phase, that is, the 12–14 days before menses, was shown to work as well as continuous treatment.[4][6][7] Although the luteal-phase treatment may be more acceptable to patients, there have been indications that by the end of a three-month period it is less well tolerated than the continuous treatment. The study authors suggested that the continuous treatment may allow the tolerance to side effects of sertraline to develop faster.[4] The most recent (2006) trial findings indicate that continuous treatment with sub-therapeutic doses of sertraline (25 mg vs. usual 50–100 mg) may both afford the highest effectiveness and minimize the side effects.[8]" It is supported by two secondary sources and six primary sources
 * 1)  Review: Pearlstein T (2002). "Selective serotonin reuptake inhibitors for premenstrual dysphoric disorder: the emerging gold standard?". Drugs 62 (13): 1869–85. doi:10.2165/00003495-200262130-00004..
 * 2)  Review: Ackermann RT, Williams JW (2002). "Rational treatment choices for non-major depressions in primary care: an evidence-based review". J Gen Intern Med 17 (4): 293–301. doi:10.1046/j.1525-1497.2002.10350.x. PMC 1495030..
 * 3)  Yonkers KA, Halbreich U, Freeman E, Brown C, Endicott J, Frank E, Parry B, Pearlstein T, Severino S, Stout A, Stone A, Harrison W. (1997). "Symptomatic improvement of premenstrual dysphoric disorder with sertraline treatment. A randomized controlled trial. Sertraline Premenstrual Dysphoric Collaborative Study Group". The Journal of the American Medical Association 278 (12): 983–988. doi:10.1001/jama.278.12.983..
 * 4)  Freeman EW, Rickels K, Sondheimer SJ, Polansky M, Xiao S (2004). "Continuous or intermittent dosing with sertraline for patients with severe premenstrual syndrome or premenstrual dysphoric disorder". Am J Psychiatry 161 (2): 343–51. doi:10.1176/appi.ajp.161.2.343..
 * 5)  Freeman EW, Rickels K, Sondheimer SJ, Polansky M (1999). "Differential response to antidepressants in women with premenstrual syndrome/premenstrual dysphoric disorder: a randomized controlled trial". Arch. Gen. Psychiatry 56 (10): 932–9. doi:10.1001/archpsyc.56.10.932..
 * 6)  Jermain DM, Preece CK, Sykes RL, Kuehl TJ, Sulak PJ (1999). "Luteal phase sertraline treatment for premenstrual dysphoric disorder. Results of a double-blind, placebo-controlled, crossover study". Arch Fam Med 8 (4): 328–32. doi:10.1001/archfami.8.4.328..
 * 7)  Halbreich U, Bergeron R, Yonkers KA, Freeman E, Stout AL, Cohen L (2002). "Efficacy of intermittent, luteal phase sertraline treatment of premenstrual dysphoric disorder". Obstet Gynecol 100 (6): 1219–29. doi:10.1016/S0029-7844(02)02326-8..
 * 8) Kornstein SG, Pearlstein TB, Fayyad R, Farfel GM, Gillespie JA (2006). "Low-dose sertraline in the treatment of moderate-to-severe premenstrual syndrome: efficacy of 3 dosing strategies". J Clin Psychiatry 67 (10): 1624–32. doi:10.4088/JCP.v67n1020..
 * 3 is cited in 1
 * 4 was published after 1&2
 * 5 is cited in 2 supporting "Two randomized trials evaluating the primarily noradrenergic tricyclic antidepressants maprotiline and desipramine, however, failed to show significant treatment benefits when compared to either placebo or an SSRI." and in 1 supporting"
 * 6 is cited in 1
 * 7 is cited in 1
 * 8 was published after 1&2

I like Pearlstein's (2012) abstract and would like to say at least this (in our own words of course) "Selective serotonin re-uptake inhibitors have well-established efficacy for severe premenstrual syndrome and premenstrual dysphoric disorder. Efficacy has been reported with both continuous dosing (all cycle) and intermittent or luteal phase dosing (from ovulation to menses). Efficacy may be less with intermittent dosing, particularly for premenstrual physical symptoms. The efficacy of symptom-onset dosing (medication taken only on luteal days when symptoms occur) needs further systematic study."