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= Stephen J. Ryan =

Personal life
Steve Ryan was born in Honolulu, Hawaii to ______ and ______. He had 3 brothers, Richard, John, and Robert.

Lived in Hawaii for __ years before moving to

He spent the majority of his life as a child and youth in ____ where he enjoyed __ Sports, school, other___.

Activies as child/youth: Sports, Arts, school,

Non-professinoal Activities as adult: Tennis….

Like his fathers, Steve Ryan became an ophthalmologist and ascended in prominence as a physician, scientist, patient advocate, and leader. Ryan was loved and appreciated by his comrades at the Cave Man Camp at the Bohemian Grove. Haig  G. Mardikian, the captain of the Camp noted “His enthusiasm was infectious…. and was often  called upon  to  be our  after lunch  speaker, at  which time  he would bring us  all  up to date on the  latest breakthroughs  in medical technology  as well  as sharing  with  us his pride in  the remarkable  work of the Doheny  Eye Institute and  his beloved USC. His love  of humor  was always  present in his  remarks, causing  even  the most  dim-witted  of us, to stay  alert, and  begin to have  an understanding  of the complicated  world of medicine in  which Steve excelled” [Haig Markidian]

He is survived by his wife, Anne, and daughter, Patricia, and brothers, Richard, John, and Robert, sisters-in-law, brothers-in-law, nephews, nieces, and his many friends.

Education and Training
Stephen Ryan attended Georgetown Preparatory School and Graduated from high school in 1957. He attended Providence College where he would earn a bachelor’s degree in Biology summa cum laude in 1961. He matriculated to Johns Hopkins Medical School where he earned in Medical Doctorate in 1965. He completed his internship at Bellevue Hospital in New York in 1966 and returned to The Johns Hopkins Hospital where he trained to be an ophthalmologist at the Wilmer Ophthalmological Instititute from 1966-1969. Ryan credited Ed Maumenee MD as his role model during his residency and faculty years at Wilmer. As a resident, Dr. Ryan was noted for describing the condition currently known as birdshot chorioretinopathy. His impact on his colleagues and on the field of ophthalmology at a young age earned him the role of Chief resident at Wilmer Ophthalmological Institute from 1969-1970 prior to completing a fellowship in Ophthalmic Pathology at the Armed Forces Institute of Pathology from 1970-1971. Later in his career he was honored with Doctor of Science (honoris causa) in 1977 from his alma mater, Providence College. The University of Leipzig awarded him a Doctor of Medicine (honoris causa) in 2006.

Professional Life
Doheny Eye institute - Medical Director beginning 1977

Dean of Keck School of Medicine and USC

Member of Institute of Medicine of National Academy of Sciences

Beckman Foundation

Clinical Practice
Dr. Ryan was board certified by the American Board of Ophthalmology in 1971 and held licensure in California, Florida, and Maryland. He was an internationally recognized expert in the field of retinal diseases and ocular trauma which guided significant portions of his clinical practice and research. During his career he held both academic and foundational appointments. He started his career as an attending at Johns Hopkins University where he ascended from role as a clinical instructor to an associate professor in four years. He and his family moved to Los Angeles in 1974 where he would serve in many prominent roles at the University of Southern California. His clinical practice grew with the beginnings of the new department of ophthalmology at the Los Angeles General Hospital (now Los Angeles County Hospital) where he developed broad expertise in general ophthalmology with foci in ophthalmic trauma and retinal disease. Ryan with two dear friend, Ron Smith MD and Mike Allen MD, undertook personal financial risk by placing their homes as collateral secured a $250,000 loan and without any institutional support, established the University of Southern California’s first private practice. Years later, the University would expand its private health care network to what is currently Keck Medicine of USC. Ron Smith would later comment, “There were some major challenges at the beginning! There was probably a less than 50-50 chance of success during those early years, but adherence to core principles, especially Mission-Vision-Values, guided us through those challenging times. (I think my hair turned gray that first year! I know my bank account ran dry!). “ By these initial steps, Ryan “devoted his life to pursuing Estelle Doheney’s 1947 vision and mission ‘… to further the conservation, improvement, and restoration of human eyesight.’” [R.E.Smith]

In 1975, Ryan secured a relationship with the Carrie Estelle Doheny Foundation to build the Doheny Vision Research Center (DVRC) where both clinical and research frontiers were merged. This partnership would elevate the ophthalmology department to a nationally top 10 ranked department. In 1992, the DVRC was dedicated to research and the new Doheny Eye Institute clinical care building was erected and is currently the home of the department of Ophthalmology for USC.

For the remainder of his career he identified clinical challenges in the areas of ocular trauma and retinal disease which he would investigate in his research lab and translate his findings to new clinical practices that influenced patient care around the world. Dr Ryan’s clinical practice in later life…..

Research
Ryan was a National Eye Institute grantee for much of his career as he was RO1 funded for 35 continuous years, produced over 300 scientific publications.

Ryan developed several animal models of retinal disease that have facilitated research and informed treatment strategies most notably for choroidal neovascularization (a consequence of conditions such as age related macular degeneration) and retinal detachment due to trauma. His primate models of ophthalmic trauma guide the clinical and surgical approaches to vitrectomy in the context of vitreous hemorrhage. Ryan’s research work continues with his collaborators, David Hinton and Shikun He studying cellular proliferation and their impact on retinal disease.

International Work
Key Organizations

Smaller organizations

National Organizations
Steve Ryan helped to establish the National Eye Institute as he garnered leadership experience with from his mentor, A Ed Maumenee, while traveling together to testify in favor of vision care to congress. He would later serve the National Advisory Eye Council (1982-1985) and steer the NEI research agenda. In 1997, Ryan established the National Alliance for Eye and Vision Research (NAEVR), which advocates for federal support for the NEI. As an internationally respected expert Dr. Ryan was a continuous source of testimony in congress providing 3 decades of advocacy for the NIH and the National Eye Institute (NIH). He also served the Institute of Medicine for over a decade in roles including Home Secretary and chair of the Membership Committee for which he ensured fair and consistent election of extraordinary individuals [Fineberg, IOM 2013].

His success as a leader in the field built the Doheny Eye Institute at USC into a premier ophthalmological center dedicated to excellence in three core missions: Patient Care, Education and Research. His approach to leadership was summarized by JAMA Ophthalmology in 2012 where he emphasized “the capacity to listen and grow, curiosity and respect for others, and to earn the trust of those in your organization and team.”

Key Roles at National Institute of Health (NIH):

1975 to 1979: Visual Sciences "A" Study Section in the Division of Research Grants

1982 to 1985: Member of the NIH National Advisory Eye Council (NAEC). Chair of Retina Panel for the NAEC.

Service on Boards:
-         The Arnold and Mabel Beckman Foundation

-         Allergan, Inc.,

-         The Johns Hopkins Health System

-         W. M. Keck Foundation.

Ophthalmologic organizations and Roles:
-         Association of University Professors of Ophthalmology (President)

-         Macula Society (President)

-         Alliance for Eye and Vision Research (Founding President)

Awards and Honors
Dr. Ryan received 31 professional awards: In November 2012 Steve Ryan was given the highest award achievable by an ophthalmologist when he was named a Laureate of the American Academy of Ophthalmology at the national American Academy of Ophthalmology meeting in Chicago, Illinois. Other notable awards included: Senior Honor Award, and the Distinguished Service Award, the Research to Prevent Blindness, Inc., Louis B. Mayer Scholar Award, the Association for Research in Vision and Ophthalmology Kupfer Award for Distinguished Public Service, the Pan-American Association of Ophthalmology Benjamin Boyd Humanitarian Award, the Fight for Sight/Mildred Weisenfeld Lifetime Research Achievement Award, and the American Ophthalmological Society Lucien Howe Medal, Doheny Professional Association Lifetime Achieve Award, and The Johns Hopkins University Society of Scholars Award and the Distinguished Alumnus Award.

Ryan propagated the tradition of recognizing and celebrating  other’s excellence by establishing the Doheny Society of Scholars.

Named Lectures – Spanning 1971-2011, Dr Ryan was an invited speaker in 40 named lectures some of which included _____

Legacy
Dr. Ryans legacy extends well beyond the contents of his professional resume. At a service to the memory of Dr Ryan Held over June 19-20, 2013 in Los Angeles with invited speakers and lecturers from around the world attending, there was one prevailing them: Stephen Ryan’s expansive contributions were rooted in his ability to care for everyone with whom he worked. Speaker after speaker noted forthright gentlemanly behavior, mindful honesty, and kindness as his fundamental characteristics. His professional legacy rests on the positive momentum with which he propelled all who surrounded him.

“He was a visionary and an optimist - a warm and open-hearted man who loved life and loved people. “ (LA times) "Steve was one of the giants of ophthalmology and, indeed, of medicine … He had a great impact in many dimensions, including his involvement in the early days of the formation of the NEI. Steve once told me that he would accompany Ed Maumenee in driving from Baltimore to Washington to visit congressional offices and to advocate that the nation should have a medical institute at the NIH with a focus on preserving and treating vision disorders. Steve had an eloquent voice and presentation, and I am sure that he held sway on those occasions. We owe Steve a debt of gratitude for his contribution in establishing NEI." NEI Director Paul A. Sieving, M.D., Ph.D on Ryan’s Life (2013) ".. he achieved greatly in all areas to which he turned his interest and considerable talent. Humble person despite all his many achievements. A great listener who genuinely cared… greatly for all people." (David Pyott)

Publications
Steve Ryan’s publications spanned several decades dating back to 1955 and totaling 325 peer-reviewed journal articles on pubmed and 291 book chapters at the time of his death.

Books:

Dr. Ryan is most widely known for his 3 volume series “Retina” for which he was editor-in-chief. This publication

A complete list of Dr. Ryan's publications can be found on pubmed