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Dr. Achal Kumar Srivastava is Professor of Clinical Neurophysiology in the Department of Neurology at the All India Institute of Medical Sciences, New Delhi, India. He heads the Clinical Neurophysiology facility and Ataxia clinic at the center and is a member of the Comprehensive Epilepsy care team here. He has special interest in ataxias, epilepsy and genetics of movement disorders. He is a recipient of more than 25 paper presentation awards and has more than 100 publications to his credit.

Biography
Dr. Srivastava graduated from MLN Medical College, Allahabad, Uttar Pradesh in 1991 and completed his postgraduate degree (MD) in Medicine (1994) from the same college. Subsequently he obtained post-doctoral specialist certification in DM (Neurology) in 1998 from the Department of Neurology, All India Institute of Medical Sciences, New Delhi. He worked as Senior Scientist grade scientist fellow for over a year at CSIR Institute of Genomics and Integrative Biology (formerly known as Center for Biochemical technology) and then joined as Assistant Professor in the Department of Neurology in March 2001. He has keen interest in teaching and has provided guidance and training to more than 70 DM and PhD students in their research work.

Dr. Srivastava has received academic awards at National and International scientific forums, mainly for his work in the field of ataxias and genetics of neurological disorders. Many of his students (both DM and PhD) have also won academic awards and honours, under his guidance. He was invited by Molecular Biology Division at John Hopkins USA for presentation of his work on spinocerebellar ataxia type 12. He has received outstanding paper presentation award from AINA at American Academy of Neurology conference at San Francisco in 2004 and the best paper award at Neurological Society of India conference at Hyderabad in 1998. He has received many travel fellowships to attend international conferences. He has received Young investigator award for CAG triplet repeat disorder conferences a has received academic awards at National and International scientific forums, mainly for his work in the field of ataxias and genetics of neurological disorders. Many of his students (both DM and PhD) have also won academic awards and honours, under his guidance. He was invited by Molecular Biology Division at John Hopkins USA for presentation of his work on spinocerebellar ataxia type 12. He has received outstanding paper presentation award from AINA at American Academy of Neurology conference at San Francisco in 2004 and the best paper award at Neurological Society of India conference at Hyderabad in 1998. He has received many travel fellowships to attend international conferences. He has received Young investigator award for CAG triplet repeat disorder conferences a

Clinical Experience

 * Worked as Resident Medical Officer in Department of Medicine at S.R.N. Hospital, Allahabad, India. for 3 years (2nd May’ 91 to 1st May’ 94).  Worked as Senior Medical Officer in Department of Medicine at Escorts Hospital and Research Centre, Faridabad, Haryana, India for about 10 months (5th May’94 to 15th Feb’95).
 * Worked as Senior Resident in Department of Neurology at Safdarjung Hospital, New Delhi, India for about one and half years (10th March’95 to 7th Oct’96).
 * Worked as Senior Resident in Department of Neurology at Neurosciences Centre, AIIMS, New Delhi, India for 2 years (from 8th Oct’96) and was awarded DM degree in Neurology in Dec.’98 in first attempt. Work included teaching assignment also.
 * Worked as Senior Resident in Department of Neurology (Post DM) at Neurosciences Center, AIIMS, New Delhi, India for 1 year and 2 months (from 8th Oct' 1998 to 7th Dec 1999). Work included teaching assignments.
 * Worked as Scientist fellow (Senior Scientist Grade) in Department of Neurology, Neurosciences Center, AIIMS, New Delhi, India for 1 year and 3 months under the project “Program on Functional Genomics” posted from Center for Biochemical Technology, Council for Scientific Industrial Research (CSIR), Delhi (from 6th Jan’ 2000 to 21st Mar’ 2001). Work included clinical evaluation of patients with hereditary ataxia suitable for genetic studies. I was exposed to lab work as well.
 * Worked as Assistant Professor of Neurology (Adhoc) at Department of Neurology, Neurosciences Center, AIIMS, New Delhi, India since 22 Mar’ 2001 to 22 September 2005. I ran Stroke clinic for Unit -1 Neurology apart from regular OPD, teaching undergraduates, junior and senior residents, DM candidates, nursing students and speech therapy students.
 * Worked as Associate Professor at Department of Neurology, Neurosciences Center, AIIMS, New Delhi, India since 23 Sep’ 2005 to June 2009. I ran intractable epilepsy clinic, Ataxia Clinic for Unit -1 Neurology apart from regular work, teaching undergraduates, junior and senior residents, DM candidates, nursing students and speech therapy students. I was in-charge of Clinical Neurophysiology facility at this center.
 * Worked as Additional Professor at Department of Neurology, Neurosciences Center, AIIMS, New Delhi, India since July 2009 to June 20013. I am running intractable epilepsy clinic, Ataxia Clinic for Unit -1 Neurology apart from regular work, teaching undergraduates, junior and senior residents, DM candidates, nursing students and speech therapy students. I am in-charge of Clinical Neurophysiology facility at this center.
 * Presently working as Professor at Department of Neurology, Neurosciences Center, AIIMS, New Delhi, India since 1st July’ 2013. I am running intractable epilepsy clinic, Ataxia Clinic for Unit -1 Neurology apart from regular work, teaching undergraduates, junior and senior residents, DM candidates, nursing students and speech therapy students. I am head of Clinical Neurophysiology facility at this center.

Courses Attended

 * 1) Paper of honour in Physiology and Social and Preventive Medicine (SPM) and passed MBBS with 1st Division (60.0% marks in aggregate).
 * 2) Best paper award at 48th Annual Conference of Neurological Society of India, 14-17 December 1999 held at Hyderabad, India for the original work “A study of factors delaying hospital arrival in patients with acute stroke”.

Bibliography (Publications)

 * 1) Srivastava AK, Goel UC, Dwivedi NC, Bajaj S. Visual Evoked Response in Ethambutol induced optic Neuritis. J Assoc Physicians India. 1997; 45: 847-849.
 * 2) Srivastava AK, Choudhry S, Gopinath MS, Tripathi M, Brahmachari SK, Jain S. Molecular and clinical correlation in five Indian families with Spinocerebellar ataxia 12. Annals of Neurology 2001; 50:796-800.
 * 3) Behari M, Srivastava AK, Das Radhika R, Pandey RM. Risk factors of Parkinson’s disease in Indian Patients. Jr. of Neurological Sciences 2001; 190:49-55.
 * 4) Choudhry S, Mukerji M, Srivastava AK, Jain S, Brahmachari SK. CAG repeat instability at SCA 2 locus: anchoring CAA interruptions and linked single nucleotide polymorphisms. Human Molecular Genetics 2001; 10(21):2437-2446.
 * 5) Srivastava AK, Prasad K. A study of factors delaying hospital arrival of patients with acute stroke. Neurology India 2001; 49:272-276.
 * 6) Srivastava AK, Khanna N, Sardana V, Gaikwad SB, Prasad K, Behari M. Cerebral venous thrombosis in ulcerative colitis: A case report. Neurology India 2002; 50:215-217.
 * 7) Srivastava AK, Tripathi M, Padma MV, Gaikwad SB, Jain S. Internuclear ophthalmoplegia and torsional nystagmus: an MRI correlate. Neurology India 2003; 51(2):271-272.
 * 8) Jain S, Tripathi M, Srivastava AK, Narula A. Phenotypic analysis of Juvenile Myoclonic Epilepsy in Indian Families.  Acta Neurologica Scandinavica 2003: 107(5):356-362.
 * 9) Kumar VG, Bhatia M, Tripathi M, Srivastava AK, Jain S. Restless legs Syndrome: diagnosis and treatment. J Assoc Physicians India. 2003; 51:782-783.
 * 10) Lazarus JP, Bhatia M, Shukla G, Padma MV, Tripathi M, Srivastava AK, Singh MB, Sagar R, Jain S. A study of nonepileptic seizures in an Indian population.Epilepsy Behav. 2003; 5: 496-499.
 * 11) Gaikwad SB, Garg A, Mishra NK, Gupta V, Srivastava AK, Sarkar C. Cerebrotendinous Xanthomatosis – Neuroimaging finding in two siblings from Indian family. Neurology India 2003; 51(3): 401-403.
 * 12) Pradeep Kumar VG, Bhatia M, Tripathi M, Srivastava AK, Jain S. Obstructive sleep apnoea: a case-control study. Neurology India 2003; 51(4):497-499.
 * 13) Srivastava AK, Sardana V, Prasad K, Behari M. Diagnostic Dilemma In Flaccid Paralysis Following Anti Rabies Vaccine. Neurology India 2004; 52(1): 132-133.
 * 14) Shukla G, Bhatia M, Vivekanandan S, Gupta N, Tripathi M, Srivastava AK, Pandey RM, Jain S. Serum prolactin levels for differentiation of nonepileptic versus true seizures: limited utility. Epilepsy Behav. 2004; 4: 517- 521.
 * 15) Jain S, Bhatia M, Tripathi M, Srivastava AK, Padma MV, Pandey RM. Seizures among families of Indian probands with different epileptic syndromes. Acta Neurologica Scandinavica 2004; 110(1): 27-38.
 * 16) Pandey N, Mittal U, Srivastava AK, Mukerji M. SMRCA2 and THAP11: potential candidates for polyglutamine disorders as evidenced from polymorphism and protein folding stimulation studies. J Hum Genet. 2004; 49(11):596-602.
 * 17) Padiath QS, Srivastava AK, Roy S, Jain S, Brahmachari SK. Identification of a novel 45 repeat unstable allele associated with a disease phenotype at the MJD/SCA3 locus. Am J Med Genet B Neuropsychiatr Genet. 2005 Feb 5; 133(1):124 -126.
 * 18) Mittal U, Srivastava AK, Jain Satish, Jain Sanjeev, Mukerji M. Founder haplotype for Machado-Joseph disease in the Indian population: novel insights from history and polymorphism studies. Arch Neurol. 2005 Apr; 62(4):637-640.
 * 19) Mittal U, Roy S, Jain S, Srivastava AK, Mukerji M. Post-zygotic de novo trinucleotide repeat expansion at spinocerebellar ataxia type 7 locus: evidence from  an Indian family. J Hum Genet. 2005; 5 (3) 155 -157.
 * 20) Anand K, Jain S, Paul E, Srivastava AK, Sahariah SA, Kapoor SK. Development of Validated Clinical case definition of Generalized Tonic-Clonic Seizures for use by community-based Health Care Providers. Epilepsia 2005; 46(5); 743-50.
 * 21) Behari M, Srivastava AK, Pandey RM. Quality of Life in Indian Patients with Parkinson’s disease. Parkinsonism Relat Disord. 2005 Jun; 11(4):221-226
 * 22) Mittal U, Sharma S, Chopra R, Dheeraj K, Pal PK, Srivastava AK, Mukerji M. Insights into the mutational history and prevalence of SCA1 in the Indian population through anchored polymorphisms. Hum Genet. 2005 Aug 17;:1-8
 * 23) Bahl S, Virdi K, Mittal U, Sachdeva MP, Kalla AK, Holmes SE, O'hearn E, Margolis RL, Jain S, Srivastava AK, Mukerji M. Evidence of a Common Founder for SCA12 in the Indian Population. Ann Hum Genet. 2005 Sep; 69(5):528-534.
 * 24) Shukla G, Bhatia M, Padma Srivastava MV, Tripathi M, Srivastava AK, Singh VP, Sarachandra P, Gupta A, Gaikwad S, Bal CS, Jain S. Unidirectional whole body turning: a new lateralizing sign in complex partial seizures. J Neurol Neurosurg Psychiatry. 2005 Dec; 76(12):1726-1729.
 * 25) Padma MV, Singh MB, Bhatia R, Srivastava AK, Tripathi M, Shukla G, Goyal V, Singh S, Prasad K, Behari M. Hyperacute thrombolysis with IV rtPA of acute ischemic stroke: efficacy and safety profile of 54 patients at a tertiary referral center in a developing country. Neurol India. 2007 Jan-Mar;55(1):46-9.
 * 26) Shukla G, Singh S, Goyal V, Gaikwad S, Srivastava AK, Bal CS, Gupta A, Behari M. Prolonged preictal psychosis in refractory seizures: a report of three cases. Epilepsy Behav. 2008 Jul;13(1):252-5.
 * 27) Faruq M, Scaria V, Singh I, Tyagi S, Srivastava AK, Mukerji M. SCA-LSVD: a repeat-oriented locus-specific variation database for genotype to phenotype correlations in spinocerebellar ataxias. Hum Mutat. 2009 Jul;30(7):1037-42.
 * 28) Bhardwaj A, Mukerji M, Sharma S, Paul J, Gokhale CS, Srivastava AK, Tiwari S. tSNPscore: a combined evidence approach for assessing cumulative impact of mitochondrial variations in disease. BMC Bioinformatics. 2009 Aug 27;10 Suppl 8:S7.
 * 29) Singh I, Faruq M, Mukherjee O, Jain S, Pal PK, Srivastav MV, Behari M, Srivastava AK, Mukerji M. North and South Indian populations share a common ancestral origin of Friedreich's ataxia but vary in age of GAA repeat expansion. Ann Hum Genet. 2010 May;74(3):202-10.
 * 30) Vibha D, Sureshbabu S, Shukla G, Goyal V, Srivastava AK, Singh S, Behari M. Differences between familial and sporadic Parkinson's disease. Parkinsonism Relat Disord. 2010 Aug;16(7):486-7.
 * 31) Vibha D, Shukla G, Singh S, Goyal V, Srivastava AK, Behari M. Lower prevalence of sleep disturbances in familial versus sporadic Parkinson's disease: a questionnaire based study. J Neurol Sci. 2010 Aug 15;295(1-2):27-30.
 * 32) Desai SD, Shukla G, Goyal V, Singh S, Padma MV, Tripathi M, Srivastava AK, Singh M, Shivakumar K, Sagar R, Behari M. Study of DSM-IV Axis I psychiatric disorders in patients with refractory complex partial seizures using a short structured clinical interview. Epilepsy Behav. 2010 Nov;19(3):301-5.
 * 33) Swarup V, Srivastava AK, Padma MV, Rajeswari MR. Quantification of circulating plasma DNA in Friedreich's ataxia and spinocerebellar ataxia types 2 and 12. DNA Cell Biol. 2011, Jun;30(6):389-94.
 * 34) Prasad K, Kumar A, Sahu JK, Srivastava MV, Mohanty S, Bhatia R, Gaikwad SB,Srivastava A, Goyal V, Tripathi M, Bal C, Mishra NK. Mobilization of Stem Cells Using G-CSF for Acute Ischemic Stroke: A Randomized Controlled, Pilot Study. Stroke Res Treat. 2011;2011:283473. doi: 10.4061/2011/283473. Epub 2011 Oct 11
 * 35) Srijithesh PR, Shukla G, Srivastava AK, Goyal V, Singh S, Behari M. Validity of the Berlin Questionnaire in identifying obstructive sleep apnea syndrome when administered to the informants of stroke patients. J Clin Neurosci. 2011 Mar;18(3) :340-3.
 * 36) Nanda A, Jain V, Srivastava AK. An electromyographic study to assess the minimal time duration for using the splint to raise the vertical dimension in patients with generalized attrition of teeth. Indian J Dent Res. 2011 Mar-Apr;22(2):303-8.
 * 37) Vibha D, Shukla G, Goyal V, Singh S, Srivastava AK, Behari M. RBD in Parkinson's disease: a clinical case control study from North India. Clin Neurol Neurosurg. 2011 Jul;113(6):472-6
 * 38) Swarup V, Srivastava AK, Rajeswari MR. Identification and quantification of differentially expressed proteins in plasma of spinocerebellarataxia type 12. Neurosci Res. 2012 Jun;73(2):161-7.
 * 39) Rai NK, Srivastava AK, Pahwa S, Garg A. Idiopathic thrombocytopenic purpura and neuropathy: A case report and review. Neurology Asia 2012; 17(1) : 63 – 66.
 * 40) Shukla G, Gupta S, Goyal V, Singh S, Srivastava AK, Behari M. Abnormal sympathetic hyper-reactivity in patients with myasthenia gravis: a prospective study. Clin Neurol Neurosurg. 2013 Feb;115(2):179-86.
 * 41) Zanzmera P, Shukla G, Gupta A, Singh H, Goyal V, Srivastava AK, Behari M. Markedly disturbed sleep in medically refractory compared to controlled epilepsy - a clinical and polysomnography study. Seizure. 2012 Sep;21(7):487-90.
 * 42) Gupta A, Shukla G, Goyal V, Srivastava A, Behari M. Clinical and polysomnographic characteristics in 20 North Indian patients with narcolepsy: a seven-year experience from a neurology service sleep clinic. Neurol India. 2012 Jan-Feb;60(1):75-8.
 * 43) Batla A, Goyal C, Shukla G, Goyal V, Srivastava AK, Behari M. Hemifacial spasm: clinical characteristics of 321 Indian patients. J Neurol. 2012 Aug;259(8):1561-5.
 * 44) Prasad K, Mohanty S, Bhatia R, Srivastava MV, Garg A, Srivastava A, Goyal V, Tripathi M, Kumar A, Bal C, Vij A, Mishra NK. Autologous intravenous bone marrow mononuclear cell therapy for patients with subacute ischaemic stroke: a pilot study. Indian J Med Res. 2012 Aug;136(2):221-8.
 * 45) Kaul B, Shukla G, Goyal V, Srivastava AK, Behari M. Paroxysmal occipital discharges suppressed by eye opening: spectrum of clinical and imaging features at a tertiary care center in India. Neurol India. 2012 Sep-Oct;60(5):461-4.
 * 46) Shukla G, Goyal V, Srivastava AK, Behari M. Quantitative thermal sensory testing and sympathetic skin response in primary Restless legs syndrome – A prospective study on 57 Indian patients. Ann Indian Acad Neurol. 2012 Oct;15(4):260-2.
 * 47) Yadav R, Prasad K, Padma VM, Srivastava AK, Tripathi M, Bhatia R. Influence of socioeconomic status on in-hospital mortality and morbidity after stroke in India: retrospective hospital-based cohort study. Indian J Community Med. 2013 Jan;38(1):39-41.
 * 48) Chakrabarty B, Kabra SK, Gulati S, Toteja GS, Lodha R, Kabra M, Pandey RM, Srivastava AK. Peripheral neuropathy in cystic fibrosis: a prevalence study. J Cyst Fibros. 2013 Dec;12(6):754-60.
 * 49) Swarup V, Srivastava AK, Padma MV, Moganty RR. Quantitative Profiling and Identification of Plasma Proteins of Spinocerebellar Ataxia Type 2 Patients. Neurodegenerative Diseases. 2013, 12(4):199-206.
 * 50) Shukla G, Gupta S, Goyal V, Singh S, Srivastava AK, Behari M. Abnormal sympathetic hyper-reactivity in patients with myasthenia gravis: a prospective study. Clin Neurol Neurosurg. 2013 Feb;115(2):179-86.
 * 51) Zanzmera P, Shukla G, Gupta A, Goyal V, Srivastava AK, Garg A, Bal CS, Suri A, Behari M. Effect of successful epilepsy surgery on subjective and objective sleep parameters--a prospective study. Sleep Med. 2013 Apr;14(4):333-8.