User:Anxietycello/sandbox

Pharmaceutical quality control is a laboratory-based process that ensures that drugs meet specification during pharmaceutical manufacturing. It involves a series of laboratory techniques including but not limited to:


 * Techniques that are used to monitor the chemical concentration of active ingredient
 * Assay / degradation
 * Uniformity of content
 * Thin layer chromatography
 * High performance liquid chromatography
 * Ultra performance liquid chromatography
 * Gas chromatography
 * Infrared spectroscopy
 * Ultraviolet–visible spectroscopy


 * Techniques that monitor the physical properties of the drug
 * Hausner ratio
 * Sieve analysis
 * The average weight of a tablet
 * Tablet hardness testing
 * Friability
 * Loss on drying (i.e. Moisture analysis - also Karl Fischer titration)
 * Dissolution (chemistry) (i.e. solubility)
 * Disintegration


 * Techniques that verify the suitability of manufacturing apparatus
 * Cleaning validation

If drugs meet specification, a Qualified Person releases the drug to general sale. Quality control is an integral part of manufacturing so as to ensure the drug behaves as intended, and reduces the chance of a drug recall.

Equipment used

 * analytical balance
 * pipette
 * volumetric flask
 * shaker (laboratory)/magnetic stirrer/sonicator
 * vacuum oven
 * dessicator
 * hardness tester
 * friabilator
 * disintegration tester
 * dissolution bath