User:Aparna.gopal/sandbox



Dr. Paul Kubes (born April 23, 1962) is an internationally recognized Canadian immunologist specializing in visualizing the role of immune cells such as neutrophils, monocytes, NKT cells and Kupffer cellsduring infection and inflammation. He is a Professor at the University of Calgary’s Faculty of Medicine and the Founding Director of the Snyder Institute for Chronic Disease. He was named the Canada’s Health Researcher of the Year by the Canadian Institutes of Health Research (CIHR) in 2011 for his work in examining the role that white blood cells (leukocytes) play in preventing and reversing sepsis by imaging of the immune system.

Personal life
Born in Czechoslovakia, Dr. Kubes came with his family to Canada after escaping from Russian invasion in 1968. After immigrating to Canada, his father George Kubes worked at McGill as a professor in Chemical Engineering and his mother Milena was a psychologist.

Dr. Kubes has 2 daughters Kaylyn and Riley (20 and 16 years of age) and 6 weeks old twins Jasper and Jake.

Education
Dr. Kubes received his college degree in 1981 from John Abbott College, Quebec, Canada in Health Science. and his BscHons, MSc and PhD degrees from Queen’s University, Ontario, Canada. He completed his BScHons in 1984 under the guidance of Dr. P. Johansen.

Later, under the supervision of Dr. Chris Chapler, he completed his MSc in 1986 and PhD degree in 1988 in the area of Cardiovascular Physiology.

Career and Research
Dr. Kubes credits the education and research experience he received during his graduate studies as being integral to shaping his early research career. During the final year of his PhD, Dr. Kubes attended a Bowditch lecture given by Dr. Neil Granger which centered aroundthe concept that immune cells might notice injury and imaging the white cells infiltrating a post-ischemic tissue. Inspired by the imaging techniques presented and the concept of cardiovascular and immune relationship, he went on to work with Dr. Neil Granger at Louisiana State University (LSU) Medical Centeron a post-doctoral fellowship in 1988. His post-doctoral research involved studying the excessive inflammation associated with heart attacks and strokes. It was while he was working here that he had his first success in developing a system to visualize the behaviour of leukocytes in blood vessels under normal conditions and heart conditions like an ischemic episode in the heart. After working at LSU for 3 years he returned to Canada in 1991 to take up a position as an Assistant Professor at the University of Calgary. Here he continued to study the mechanisms that lead to recruitment of leukocytes in cardiovascular diseases. Since then he has branched his field of research tounderstand leukocyte recruitment in various models of inflammatory disease in various tissues including the brain, liver and the gut. He currently holds a full Professor position at the University of Calgary’s Faculty of Medicine, Department of Physiology and Pharmacology. The current primary focus of his lab is to directly visualize the roles of immune cells during inflammation, infection and tissue injuryusing cutting edge technology, including spinning-disk confocal, resonant-scanning confocal, and multi-photon microscopy

In 2008, Dr. Kubes played an instrumental role in forming the Snyder Institute for Chronic Diseases and has been the founding director of the institute since then.

Awards and Achievements
Dr. Kubes and his team identified that an endogenously produced gas, nitric oxide, functions to reduce leukocyte recruitment. He was one of the first to use inhaled NO as a potential therapy for excessive inflammation during infections and other autoimmune disorders. He holds a Canada Research Chair in Leukocyte Recruitment in Inflammatory Disease and has spent years understanding the underlying causes of chronic ailments. He is also appointed as the Snyder Research Chair in Critical Care Medicine and has used the money to develop and operate a translational laboratory that supports critical care clinical trials with molecular lab tests. Along with a group of professors at the University of Calgary, Dr. Kubes has created a training program geared towards elucidating the cellular, molecular, and physiologic mechanisms of infectious and immune disease and a clinical program entitled the AHFMR Alberta Sepsis Network. Any patient that enters an Alberta ICU enters this program.

In recognition of his research contributions Dr. Kubes has received several national and internationally recognized awards. He received the Faculty of Medicine Smith Distinguished Achievement Award for Senior Faculty twice in 2001 and 2003. The Canadian Society Clinical Investigation (CSCI)/Royal College Physicians Surgeons Canada (RCPSC) Henry Friesen Award in 2010.

He is the only Canadian to receive the American Physiological Society, Henry Pickering Bowditch Lectureship in 2003. In 2005, he received the Alberta Science and Technology Award for Outstanding Leadership in Science. He received the Canada’s Health Researcher of the Year Award in 2011from the Canadian Institutes of Health Research (CIHR). He was also the recipient of the 2012 Canadian Society of Immunologists-Hardy Cinder Award, the Chair Gairdner Award MAB committees, Member F1000 in 2015 and the most recent the Gabor Kaley Memorial Lectureship in 2019 to name a few.

Dr. Kubes presently holds twelve peer-reviewed grants, six of which are CIHR grants. He has published over 300 peer-reviewed papers in high impact science journals including Cell, Scienceand Nature Medicineas well as clinical journals like ''Lancet. ''

Editorship and other professional services
Dr. Kubes currently sits on editorial boards of the Journal of Clinical Investigationand Journal of Experimental Medicine. He is also a guest editor for PNAS. Dr. Kubes has extensive review experience with CIHR by being part of numerous committees including the Immunology transplantation, CIHR/NIH Panel RFA: Inflammation and Thrombosis, CIHR Personnel Awardsand the Banting Peer Review.

Most Significant contributions
1.   Liew PX, Kubes P. The Neutrophil's Role During Health and Disease.Physiol Rev. 2019 Apr 1;99(2):1223-1248.

2.    Zeng Z, Surewaard BGJ, Wong CHY, Guettler C, Petri B, Burkhard R, Wyss M, Le Moual H, Devinney R, Thompson GC, Blackwood J, Joffe AR, McCoy KD, Jenne CN, Kubes P. Sex-hormone-driven innate antibodies protect females and infants against EPEC infection. Nat Immunol. 2018 Oct:19(10):1100-1111.

3.    Bogoslowski A, Butcher EC, Kubes P. Neutrophils recruited through high endothelial venules of the lymph nodes via PNAd intercept disseminating Staphylococcus aureus. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2449-2454.

4.    Wang J, Hossain M, Thanabalasuriar A, Gunzer M, Meininger C, Kubes P. Visualizing the function and fate of neutrophils in sterile injury and repair. Science. 2017 Oct 6;358(6359):111-116.

5.    Wang J, Kubes P. A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair. Cell. 2016 Apr 2;165(3):668-78.