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Eleanor Riese was diagnosed with schizophrenia at the age of 25. Her first hospitalization took place in 1968 at Saint Mary's Hospital and Medical Center, where she was prescribed, Mellaril, and continued to take for the next 11 years. By 1981, Reise had developed bladder problems, a side effect from the drug; her medication changed and she was hospitalized. Reise was then re-hospitalized in 1982 and was placed back on Mellari on the idea that her bladder was beyond functional that no amount of the dosage would not affect her recovery to stability.

On June 12, 1985 Reise returned back to the hospital as a voluntary patient. Reports indecated that Riese had stopped taking Mellari for five weeks, which caused her to become increasingly agitated, psychotic, and anxious. Upon admission Riese signed a consent form for the antipsychotic medications: Mellari, Molindane, and Cogentin, that she was informed of the nature of the drugs and the possible side effects as well her right to refuse them. On June 17, 1985 her medication was switched to Navane - without her consent, she had to take the medication four times a day. After taking the drug, Riese complained about dizziness and dry mouth and implored the staff to reduce the dosage of the medication, upon their refusal, Riese refused to take the drug and it was forcibly injected. At this point Riese's treatment became involuntary with a 14-day hold. On June 19, 1985 her medication was then switched back to Mellari. On July 10, 1985 Riese's medication was switched to Serentil through intramuscular injections. Riese continued to suffer from bladder problems, seizuresm memory loss, shaking, and swollen feet and ankles.

In 1988 Riese filed a lawsuit against Saint Mary's Medical Center for physical damage caused by the drugs she did not consent to. The court ruled unanimously that patients who were involuntary, had the right to refuse medications if they were mentally competent.