User:AquilaAking/sandbox

Proposed Changes to Endometriosis Article

1: Add new sub-section in Pathophysiology called "Oxidative Stress: Iron Overload"

2: Add new paragraph under proposed change 1: "Influx of Iron is associated with the local destruction of the peritoneal mesothelium, leading to the adhesion of ectopic endometrial cells . Peritoneal iron overload might be due to the destruction of erythrocytes, which contain the iron-binding protein hemoglobin, or a deficiency in the peritoneal iron metabolism system. "

Reference 1: Oxidative Stress and Endometriosis: A Systematic Review of the Literature. Oxid Med Cell Longev. 2017;2017:7265238. doi: 10.1155/2017/7265238. Epub 2017 Sep 19.

3: Add new sub-section in Pathophysiology called "Oxidative Stress: Reactive Oxygen Species (ROS)"

4: Add new paragraph under proposed change 3: "Oxidative stress activity and reactive oxygen species (such as superoxide anions and peroxide levels) are high in endometriosis and are known to damage tissue and induce proliferation . There are several pathways for oxidative stress to induce proliferation of endometriotic lesions such as the mitogen activated protein (MAP) kinase and extracellular signal-related kinase (ERK) pathway. Activation of both pathways lead to increased levels of c-Fos and c-Jun, proto-oncogenes associated with high-grade lesions. "

Reference 1: Oxidative Stress and Endometriosis: A Systematic Review of the Literature. Oxid Med Cell Longev. 2017;2017:7265238. doi: 10.1155/2017/7265238. Epub 2017 Sep 19.

Comments
Thanks for sharing your proposed changes and improvements.

Can you please insert all your references using the PMID tool so that it is easier to see your sources?

Can you find any Wikilinks to add to the terms? Oxidative stress, ROS etc. Wikilinks are added to the first time the term/topic is used in the Wikipedia article. I added a few, but there are many more that can be added to help people understand the evidence.

There are a few places where you can try to make the wording easier to understand for someone without a background in medicine. For example, you write "induce proliferation". Can you expand on this and use lay terms to explain what is happening? JenOttawa (talk) 15:27, 9 November 2018 (UTC)