User:Arianalramos/sandbox

Wiki 10 – Peer Review

Notes on Epigenetics of Schizophrenia

Heritability


 * The percentages mentioned at the beginning of the second paragraph are slightly confusing (80 + 30 + 30). I could be misunderstanding it, but maybe a little more context would clear it up.
 * I think the emphasis on heritability being a combination of genetic and environmental factors is important to note. Good job
 * Regarding the sentence that begins with “monozygotic and dizygotic twin studies…”, the part that says “shown that there is SZ has significant heritability” is a little bit grammatically confusing. It may be helpful to slightly rephrase.
 * The last paragraph about the effects of the immune system on the fetus is surprising and very interesting. I think “maternal effects” at the beginning of the first sentence is a little vague. It might be useful to find another description to introduce the topic. “Effects” is less impactful on its own; maybe “immune system effects” or something along those lines.

Genetics


 * In the list of genes at the beginning of this sections, their descriptions are a bit scientific. It may be helpful to try and explain them in more layman’s terms, in order to be more easily readable to a general audience.
 * Linkage studies could use more explanation, as far as what they are/what they test for.
 * The paragraph regarding linkage studies seems to be written twice, once before and after the CNV paragraph. Not sure if this was intentional!

Epigenetic alterations


 * This section is well organized and provides a good overview of each type of alteration and how they pertain to schizophrenia.
 * The title of the last subsection could be more appropriately titled? Or maybe belongs in a different section. It has a lot of interesting information about the epigenetic effects of famines on populations.

Environmental risks and causes


 * The first paragraph makes a few bold, general claims relating the development of schizophrenia to inhalation of benzene and methamphetamine. Because these claims aren’t fully fleshed out, it might be good to include a sort of disclaimer statement, saying that these claims are based on limited information or there is more research to be done in that area to confirm them. Also, it would be good to include citations here!
 * I realize this is from the original article, but in your final edits, I’d look over/verify this info
 * I really like the paragraph talking about twin studies and environmental influences. Very well written!
 * In your final edits, I think it would be a nice touch to include some links to other Wikipedia pages for things like Prenatal Maternal Stress, IL-6, or other big terms, just for ease of reference.

Detection and treatment


 * I think this is a very good section to include in this article
 * It could help to include which therapeutics, pharmacological or not, are being used right now or have been in the past.
 * What you have written so far in the italics is really good. I think the information is interesting and important. Not sure how much info is out there on this subject, but if there is more info available, this section could be expanded! If not, maybe include a statement addressing that there is more research to be done.