User:Arora.ro/sandbox

Cristae are vital in the apoptotic pathway in advanced eukaryotic organisms. Of all cytochrome c present in the mitochondria, more than 85% is found in invaginations of the cristae. Cytochrome c, when released from the outer membrane into the cytoplasm signals apoptosis. Destabilization of the crista structure has been also associated with several neurodegernative diseases. These diseases include Alzheimer's Disease, amyotrophic lateral sclerosis, and Parkinson's disease.