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Early life
Jewel Isadora Plummer was the only child of Frank V. Plummer, and Carriebel (Cole) Plummer. Her mother, Carriebel, found employment as a physical education and dance teacher who graduated from college with a B.A in interpretive dancing. Her father, Frank, was the first black person to graduate with a Doctor of Medicine from Cornell University, becoming a physician specializing in dermatology. Plummer's paternal grandfather was a freed slave who graduated from Howard University in 1898 making a living as a pharmacist.

Cobb's economically privileged upbringing offered her a childhood of intellectual exploration. From her father's scientific library to her education at several multiracial institutions, Cobb developed an interest in learning from a young age. Although she anticipated becoming a physical education teacher, her interest in science solidified during her sophomore year of high school whilst looking through a microscope in biology class.

Higher education
Cobb matriculated at the University of Michigan in 1942, but, dissatisfied with segregated housing for African-American students at Michigan, she transferred to Talladega College in Alabama. She graduated with a B.A. in biology in 1944 and became a member of the Alpha Kappa Alpha sorority.

Cobb initially was denied a fellowship for graduate study in biology at New York University, allegedly due to her race, but was granted the fellowship after an interview. She earned her M.S. degree from New York University in 1947, and her Ph.D. degree with a focus on cell physiology in 1950

Her dissertation, Mechanisms of Pigment Formation, examined melanin pigment granules formations in vitro using the enzyme tyrosinase. In 1949, she was appointed an independent investigator at Woods Hole Marine Biological Laboratory.

Professional life
After receiving her Ph.D, Cobb became a biology teaching fellow at New York University while also working for the National Cancer Institute at Harlem Hospital (1950-1952). From 1952-1954 Cobb was an instructor in anatomy in Chicago at the University of Illinois College of Medicine where she taught histology. Shortly thereafter, Cobb returned to New York, serving as an assistant professor for NYU's post graduate medical school (1955-60), while also working as a visiting lecturer at Hunter College (1956-57).

From 1960-69, Cobb was employed as head of the biology laboratory at Sarah Lawrence College. While there, she conducted undergraduate research for participants in the National Science Foundation.

Connecticut College
Cobb served as a professor of Zoology and as Dean of Arts and Sciences at Connecticut College from July 1969 until July 1976. Cobb was the first black Dean in the College's history. Upon accepting the position at Connecticut College, she expressed: "This is a college in transition, moving forward at an exciting pace. We need more black students and teachers to help us formulate and carry out our bold new plans."

During her time at Connecticut College, she implemented a Black Scholarship program that provided financial assistance to at least 37 Black undergraduates at the college. The scholarship intended to increase financial assistance needs for students of color.

Cobb also established a Fifth Year Post-Baccalaureate Pre-Medical Program, which provided financial assistance and educational opportunities for minority students at the College who wanted to pursue careers in medicine or dentistry. Students were provided with resources for tutoring and counseling. Just five years after this program was established, these students were accepted into graduate programs, which included, Yale, Georgetown, and the University of Connecticut.

While in Connecticut, Dr. Cobb also served as a member of the Lawrence and Memorial Hospital in New London, in addition to being elected Director of the American Council on Education, (1973-1976) and chairing a conference (May 1973) comprised of representatives from nineteen New England Colleges which focused on the experiences of people of color at predominately white institutions.

In July of 1976, Cobb decided to leave Connecticut College and become a dean and professor of Biological Sciences at Douglass Residential College at Rutgers University.Cobb's decision to leave was not premeditated, rather it centered on an interest in becoming a full-time administrator for the Women's division of Rutgers. Cobb's greatest hesitation in leaving the College concerned her inability to continue research to the same degree in her new role.

While at Douglass, Cobb (alongside nine other Americans) was selected by the Rockefeller Foundation to participate in a global conference in Italy concerning the future of higher education for women. Additionally, in April of 1978, Cobb was nominated by President Carter as a member of the Board of Foreign Scholarships, best known as the organization responsible for determining Fulbright eligibility.

California State University, Fullerton
Cobb was appointed President of California State University, Fullerton in 1981 where she began to improve campus facilities from the start of her term.

Cobb was successful in obtaining funds for the construction of an Engineering and Computer Science Building which was constructed with state funds, as well as the Ruby Gerontology Center, which was the first building in the College's history to be funded through private donations. She also acquired financial capital for the construction of the first ever student residence on campus. The completion of this apartment complex was later named in her honor. Cobb also negotiated an agreement with the Marriott Corporation and the city of Fullerton for a lease to construct a hotel, allowing her to use available funds for the construction of a campus sports complex. The majority of the planning for the Science Laboratory Center, now called Dan Black Hall, was done while Cobb was president.

At Fullerton, some faculty members did not share Cobb's interests in research and rebuilding, holding that the primary mission of the college was to teach. Her decision to enter into the agreement to build the hotel on campus and to add a satellite campus in the southern part of Orange County thus generated criticism on campus. Cobb brought both of these issues to the Faculty Senate for a vote. Both times, her decisions were upheld.

In 1990, aged 66, she was forced to retire under a rule imposed by W. Ann Reynolds, the Chancellor of the California State University System, requiring all campus presidents aged 65 or older to retire. In response to her departure, Julian Foster, a campus leader and prominent political scientist, expressed Cobb's emphasis on research and scholarship to be her most important contribution to Cal State Fullerton.

Shortly after retiring, Cobb was named California State University Trustee Professor for its Los Angeles division.

In 1991, she became the principal investigator at Southern California Science and Engineering ACCESS Center and Network, which assists middle school and high school students from disadvantaged backgrounds pursue a future in the fields of science and engineering.

In 2001, Cobb became the principal investigator for Science Technology Engineering Program (STEP) Up for Youth—ASCEND project at California State University, Los Angeles. She also was named and served as a member of the Caltech Board of Trustees.

Research
Cobb's research included work on the relationship between melanin and skin damage, and on the effects of hormones, ultraviolet light, and chemotherapy agents on cell division. Cobb discovered that methotrexate was effective in the treatment of certain skin cancers, lung cancers, and childhood leukemia. This drug continues to be used in chemotherapy today to treat a wide range of cancers and autoimmune diseases. Cobb was the first to publish data on actinomycin D and its ability to cause a reduction of nucleoli in the nucleus of normal and malignant human cells.

She received a $5,000 grant from the American Cancer Society to continue her research in"Direct Hormone Action to Human and Mouse Melanomas in Tissue Culture." This grant supported her research and a broader examination of pigment cell growth and differentiation in human and mouse melanomas

Other support for her cancer research came through her post-doctoral fellowship, research grants from the: Damon Runyon, National Science Foundation, National Cancer Institute, and Public Health Services.

Cobb was part of the United States International Cancer congresses in London (1958) and Moscow (1962) and served on the advisory board to Mohegan Community College. She was awarded the National Institute of Health Fellowship for $68,000, where she spent seven months in Naples, Italy continuing cell growth research at the International Laboratory of Genetics and Biophysics.

Throughput her career, she collaborated with other notable researchers, including oncologist Jane C. Wright, Grace Antikajian, and Dorothy Walker Jones. Her most influential mentors were her bacteriology professor James R. Hayden and her biochemistry professor M.J. Kopac.

In recognition of her research achievements, Cobb was elected to the Institute of Medicine in the National Academy of Sciences in 1974. She was also a member of the National Science Board from 1974 to 1980.

Additional societal contributions
Cobb was named Vice President of the Board for the 21st Century Foundation, dedicated to supporting the development of Black institutions that addressed issues in the Black community. Programs established by the organization included: economic, educational, and community development with the purpose of creating opportunities for people of color.

She was also a member of the American Association for the Advancement of Science, which supported both women and people of color in the field. Cobb was one of seven recognized by the Oakland Museum Association's Cultural and Ethnic Affairs for her contributions to science and/or technology. The museum's exhibition hoped to increase minority representation in the sciences by showcasing the accomplishments of people of color, including several of Cobb's findings.

As the keynote speaker at the 1971 Wheaton College commencement, Cobb called for an alliance between the Women's Liberation Movement and the Black Liberation Movement. She called for the equality of women, the abolition of abortion laws, and the demand for public child care in particular.

Final years & legacy
Many of the policies and programs Cobb initiated during her administrative careers take form in her 1979 paper, Filters for Women in Science, where she expressed concerns about female representation in science and engineering. Through an analogy connecting her passion for science and demand for equity, Cobb claimed that the characteristics of the filtrate passing through a filter are primarily determined by the size of the pores, which she connected with the limitations of female employment in science.

Cobb's insistence on providing resources and programs to increase minority representation at her colleges of employment define her legacy outside of the laboratory.

A former student, Timothy Yarboro, stated, "I would not have become a doctor. Because of her, I knew it was possible."

She resided in Maplewood, New Jersey, until her death on January 1, 2017 at the age of 92. Jewel Plummer Cobb is survived by her only child, Roy, a radiologist specializing in magnetic resonance imaging.