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The Neozygitaceae are a family of fungi in the order Entomophthorales. The family currently contains 3 genera: Apterivorax, Neozygites, and Thaxterosporium.

Morphology
The mycelium is coenocytic or irregularly septate. The nuclei are small. During interphase, condense chromatin is absent, but a central nucleolus can be observed. The mycelium can become disjointed. In Ancylistes, who are parasites of desmids (algae form), the hyphae grow toward the ends of the host. As the hyphae grow, branches that follow the groves between plates in the chloroplast are produced. Upon reaching the end, the hyphae grow toward the other end to completely encircle the chloroplast. Septa are produced progressively with segments containing many nuclei. Conidia are produced singly on unbranched sporophores. Like other members of Entomophthorales, conidia are forcibly discharged, which occurs through papillar eversion. Zygospores are formed along the axis of conjugation and can be angular in shape.

Sexual Reproduction
Sexual reproduction results in the formation of a zygospore that functions as a resting spore. The zygospore is formed by the fusion of gametangial cells or the scalariform fusion of hyphae. Little is known about the zygospores.

Ecology
The genus Ancylistes are parasites of desmids, a group of green algae. Macrobiotophthora are parasites of tardigrades and nematodes. The genus Conidiobolus are common saprobes and occasional parasites of vertebrates or insects. Capillidium are also parasites of vertebrates or insects.

The most well known member is Conidiobolus coronatus, which is typically found in soils and parasitizing termites and aphids but has been known to infect mammals.