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Intestinal alkaline phosphatase is an endogenous protein that plays an essential function in the maintenance of gut homeostasis. The protein is responsible for detoxifying bacterial toxins, dephosphorylating phosphorylated nucleotides, regulating lipid absorption in the intestine, and regulating the microbiome in the intestine. In addition to these functions, intestinal alkaline phosphatase can also modulate bicarbonate secretion and can modulate the pH of the duodenum.