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SAICAR → AICAR + Fumarate.

The products AICAR and fumarate move on to two different pathways. AICAR serves as the reactant for the ninth step, while fumarate is transported to the citric acid cycle which can then skip the carbon dioxide evolution steps to produce malate. The conversion of fumarate to malate is catalyzed by fumarase. In this way, fumarate connects purine synthesis to the citric acid cycle.

The ninth is catalyzed by phosphoribosylaminoimidazolecarboxamide formyltransferase.