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Source 1
Cavallaro, U., Schaffhauser, B., & Christofori, G. (2002). Cadherins and the tumour progression: Is it all in a switch? Cancer Letters, 176(2), 123-128. doi: http://dx.doi.org.portal.lib.fit.edu/10.1016/S0304-3835(01)00759-5

Source 2
Morales, C. P., Souza, R. F., & Spechler, S. J. (2002). Hallmarks of cancer progression in barrett's oesophagus. The Lancet, 360(9345), 1587-1589. doi: http://dx.doi.org.portal.lib.fit.edu/10.1016/S0140-6736(02)11569-8

Article Evaluation
Some information is from a few years ago but its been updated recently. All information relates to the topic. History and evolution could be added to the tree frogs.

The article is neutral and nothing is over or underrepresented. All information was cited from peer reviewed journals etc.

On the talk page, people are letting others know about upcoming changes and a picture of the day. It is rated C with low importance

Article Selection
Cadherins- The article for cadherins remains neutral and relevant to the topic. Each claim also has reliable citations

Cadherins and cancer correlation
It is "indicated that the loss of the cell adhesion molecule E-cadherin is causally involved in the formation of epithelial cancers (carcinomas)" [SOURCE 1]. Also, "changes in cadherin expression may not only modulate tumour cell adhesion but also affect signal transduction and, hence, the malignant phenotype." [SOURCE 1]

Why E cadherins? 'CAMs such as the cadherin glycoproteins normally function as the glue that holds cells together and as important mediators of cell-cell interactions. E-cadherin, on the surface of all epithelial cells, is linked to the actin cytoskeleton through interactions with catenins in the cytoplasm. Thus anchored to the cytoskeleton, E-cadherins on the surface of one cell can bind with those on another to form bridges. In epithelial cell cancers, disrupted cell-cell adhesion that might lead to metastases can result from abnormalities in the expression of E-cadherin or its associated catenins.26 There is an inverse relation between E-cadherin expression and neoplastic progression in Barrett’s oesophagus.2' [SOURCE 2]

E-cadherins on the surface of one cell can bind with those on another to form bridges. In epithelial cell cancers, disrupted cell-cell adhesion that might lead to metastases can result from abnormalities in the expression of E-cadherin or its associated catenins.[Source 2]

Cadherins Final Draft
It has been discovered that cadherins and other additional factors are correlated to the formation and growth of some cancers and how a tumor continues to grow. The E-cadherins also known as the epithelial cadherins on the surface of one cell can bind with those of the same kind on another to form bridges (Morales et al., 2002). It is indicated that the loss of the cell adhesion molecule E cadherin is casually involved in the formation of epithelial types of cancers such as carcinomas. The changes in any type of cadherin expression may not only control tumor cell adhesion but also affect signal transduction leading to the cancer cells growing uncontrollably (Cavallaro et al., 2002).

In epithelial cell cancers, disrupted cell to cell adhesion might lead to the development of secondary malignant growths that are distant from the primary site of cancer, can result from the abnormalities in the expression of E-cadherins or its associated catenins. CAMs such as the cadherin glycoproteins normally function as the glue that holds cells together and act as important mediators of cell to cell interactions. E-cadherins, on the surface of all epithelial cells, are linked to the actin cytoskeleton through interactions with catenins in the cytoplasm. Thus, anchored to the cytoskeleton, E-cadherins on the surface of one cell can bind with those on another to form bridges. In epithelial cell cancers, disrupted cell-cell adhesion that might lead to metastases can result from abnormalities in the expression of E-cadherin or its associated catenins (Morales et al., 2002)