User:Ashleyxiong5/sandbox

FAM234A is a protein coding gene whose full name is family with sequence similarity 234 member A.1  The gene is also known as ITFG3, gs19, and C16orf9.2  Here, the gene is explored as encoded by mRNA found in Homo sapiens. The accession number for this particular gene is NM_032029.33  The FAM234A gene is conserved in mice, rats, chickens, zebrafish, dogs, cows, frogs, chimpanzees, and rhesus monkeys1. Orthologs of the gene can be found in at least 220 organisms including the tropical clawed frog, pandas, and Chinese hamsters4. The gene is located at 16p13.3 and has a total of 19 exons. The mRNA has a total of 3224 bp and the protein has 552 aa.1,5  The molecular mass of the protein produced by this gene is 59660 Da6. It is expressed in at least 27 tissue types in humans, with the greatest presence in the duodenum, fat, small intestine, and heart.1

Little is known about the function of the FAM234A gene. A search through the GOA shows there is no biological data available on the molecular function or biological process of the gene1. A PubMed review shows that there was only one mention of the FAM234A gene. That article described a deletion endpoint of the “Newfoundland deletion” or a0-thalassemia deletion found within the second intervening sequence of the FAM234A gene7. Searches on alternative aliases for FAM234A revealed that the gene was associated with multiple red blood cell phenotypes in African Americans – though the exact function or effect of the gene was not entirely clear8. Review of GeneCards’ current database on the FAM234A gene provided no additional elucidation on the function of the gene6. A Wikipedia search of the FAM234A gene and its aliases revealed only a stub revealing little additional information.

References

1 – NCBI - Gene entry on FAM234A

2 – HGNC (HUGO Gene Nomenclature Committee) symbol report on FAM234A

3 – NCBI Nucleotide entry on Homosapiens family with sequence similarity 234 member A (FAM234A), transcript variant 1, mRNA

4 – NCBI Gene search results for FAM234A orthologs ]

5 – NCBI Protein entry on protein FAM234A [Homo sapiens]

6 – GeneCards entry on FAM234A

7 – NCBI Pub Med results for FAM234A search

8 – NCBI Pub Med results for ITFG3 search

9 – Wikipedia entry on ITFG3