User:Ashokgarande21

Ashok Malappa Garande Ashok Malappa Garande [CSIR-UGC- JRF,Ph.D(Organic Chemistry))] A/P-Gheradi., Tal- Sangloa, Dist- Solapur. Pin-413309. Email ID: amgarande@gmail.com Now, He is working on synthesis of natural product.A natural product is a chemical compound or substance produced by a living organism – found in nature that usually has a pharmacological or biological activity for use in pharmaceutical drug discovery and drug design. A natural product can be considered as such even if it can be prepared by total synthesis. Any given natural product may possess unacceptable physicochemical, pharmacodynamic, pharmacokinetic, or bioavailability properties or demonstrate excessive toxicity and will therefore require optimization of its chemical structure. The synthesis of a complicated molecule is a very difficult task since every group and atom must be placed in a proper position and with the correct stereochemistry. Indeed, the complete synthesis of natural products has been an area of interest for a long time, and the efforts to produce man-made natural products has provided significant challenge and learning opportunity over the years. The interest in preparing such molecules is due in many cases to their biological activity and in other cases to structural issues such as resolution of stereochemical assignments. The challenges involved in the synthesis of natural products are numerous and have served as a motivation to discover new reactions and improve already well-known reactions. The studies presented in this thesis are directed toward the synthesis of a novel natural product. This project was undertaken for the reasons cited above: (1) potent biological activity (2) structural issues and (3) the challenge of developing the new intermediates using conventional reactions for the synthesis of major portions of the natural  product. With such broad applications of natural products, our aim is to synthesize variety of such natural products having medicinal properties.