User:Aspires2/Week-4-Pt2

Lead
I wanted to propose edits to this Wikipedia page (Epigenome) as I feel that the information it has in regards to its applications to cancer is not that thorough and could use some additions that would allow for the discussion on cancer treatment or its applications in that area to be more fleshed out. This would include how tumor progressions in the human body can be influenced by the epigenome of the cells, as well as how epigenomes can be used to orient treatment in different cancer pathologies. I also wanted to dedicate an entire section towards cancer in general (with its own section/chapter) as I feel that the topic warrants its own section based off of how much information there is to discuss or fill out for it, especially when compared to the rest of the page itself which is not that long.

'''Have you looked at the Cancer epigenetics page? Maybe that would better place to update the quality of the cancer reporting. Probably the Epigenome page should link to the Cancer epigenetics page. Take a look and think about it. The cancer page is big but that means lots of opportunity for improvement. -- Dr. Atkinson'''

Cancer
Epigenetics is a currently active topic in cancer research. Human tumors undergo a major disruption of DNA methylation and histone modification patterns. The aberrant epigenetic landscape of the cancer cell is characterized by a global genomic hypomethylation, CpG island promoter hypermethylation of tumor suppressor genes, an altered histone code for critical genes and a global loss of monoacetylated and trimethylated histone H4.

Tumor progression in the human body can also result from a fundamental change in epigenomic environments. Caused by silencing of specific genes (such as p16, SFRPs, GATA-4 and -5, and APC in human stem cells), these epigenetic changes lead to abnormal cell growth that is propagated by the changes in the cell's ability to survive chronically stressful environments (such as Inflammation).