User:Aureliall/sandbox

Week 2 Article of interests:
Copper fist: N terminal domain involved in DNA binding.

BAFF receptor: membrane protein that respond to BAFF, which is essential for B cell survival.

Kataegis: a pattern of localized hypermutation that is related to cancer and seen in cancer genomes.

Cointegrate: the process in which donor DNA and target DNA form a Holiday complex--sounds fun!

Zbtb7: also known as the pokemon gene that might be responsible for causing cancer.

-These all have room for expansion. I don't think Cointegrate will have enough overall content to add. - Dr. Tienson-Tseng

Week 3: Assignment:

 * 1) Find the most interesting articles, and try to find five sources. (check reviews for sources and textbooks; use multiple sources)
 * 2) Make a live edit to a Wikipedia page (can be part of my page or can be irrelevant).
 * 3) Citation test! google Try wp:refeb or wp:cite All words should be original content, except for literature discussion(hopefully not applicable!)

Tried on the BAFF receptor:

BAFF receptor is responsible for B cell maturation, especially the late stage of maturation where the cell is turned into marginal zone B cell. Underexpression of BAFF-R has led to zero B cell survival in mice experiment, and overexpression may cause autoimmune disease. Overexpression of BAFF-R and BAFF pair will override the normal competitive mechanism in B cell maturation that kill the autoreactive B cells(due to limited/low expression of BAFF-R ). And BAFF-R and BAFF pair can also downregulate the cell apoptosis by activating anti-apoptotic factor through an unconventional NF-κB pathway.

Chose the article Kataegis for edition for week 5!

Week 4:
TOO MANY MIDTERMS!!!

Week 5: Draft
Saw the article and the information on protein family as well as regulation seem obscure. Need more related information and readings. Wk 5 is quite busy for me as my classics midterms kicks in. i hope i have more time to edit this paper.

Prompt: Write about your introduction to wikipedia. What did you expect? How has the experience met your expectations and how is it different? Include something you thought was really interesting about editing wikipedia or that you have learned during this process.

I thought writing in wikipedia would be extremely difficult and would require a large amount of professional knowledge; in reality, I am looking up the information as I write my article. This makes me feel good since I feel knowledgable and qualified to explain an obscure scientific concept to people, with expectation that they would listen and trust the words I say; yet at the same time, such trust is a burden. This means I have to get every single word in my wikipedia page correct, or else I could mislead someone in their study. My words need to count, so they need to be accurate and concise.

I'm a classical civilization minor, so editing Kataegis(the word means "thunderstorm" in Greek) is quite interesting for me. It is fun that the scientists named the mutation Kataegis based on its high chance of occurrences in a relatively small region of gene, that the mutations looked like raindrops from a " thunderstorm" falling down to the genome. That is a quite vivid image the scientists produced.

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The section of draft has been moved. For peer review, see User:Aureliall/draft'''

Week 8: Peer Review
Write about your experience working with Wikipedia so far. What have you found enjoyable? What has been challenging? What insights have you gained?

Wk 8 reflection:

It has been quite difficult to avoid paraphrasing, especially when most of the words from paper are very specific and thus hard to find another way of expression. I like the reading paper part--it is fun to look for new material and learn new things as a part of the course's experience. It makes me write a mental note to myself that I will be extremely clear when I write my future paper--some of the paper are extremely hard to read because of lack of explanation and abbreviation at multiple parts of the sections.

Link for pictures posted


 * 1) Kataegis experiment data.  https://commons.wikimedia.org/wiki/File:Rainplot_for_Kataegis_in_Breast_Cancer_Genome.jpg

