User:Awotawa1/sandbox

Wikipedia's Five Pillars

 * 1) Numbered list item Wikipedia is an online encyclopedia.
 * 2) Numbered list item Wikipedia has a neutral viewpoint.
 * 3) Numbered list item Wikipedia content is free.
 * 4) Numbered list item Wikipedians should interact respectfully and in a civil manner.
 * 5) Numbered list item Wikipedia has no firm rules.


 * Indented line Wikipedia is an online encyclopedia that dissemminates knowledge much like that of general and specialized encyclopedias, almanacs, and gazettes. It is not a forum to promote one's own self or agenda. Articles and edits are to be impartial and state objective facts. Content is free; however, all copyright laws should be followed and plagarism should not take place. Anyone can contribute to an article, and edit and modify it. Use proper etiquette when disagreements arise, be respectful, and civilly discuss differences in opinion. Be bold (not reckless) when editing an article or contributing content, and don't worry about making mistakes.

Summary of characteristics of target article
A good quality article will be well-written, contain referenced facts from multiple sources, contain no plagiarism, and maintain a neutral tone. All references should be properly cited so facts can be easily verified and should be from reliable sources, such as journal articles and textbooks. It should contain no original research, remain broad in coverage, but stay focused on the topic. Images and illustrations should be used when appropriate and copyright licenses should be honored. Wiki users can view guidelines by referring to Wikipedia's article grades.

Inline Citation Practice
The tumor microenvironment plays a critical role in multiple myeloma (MM) growth, progression, and drug resistance. It provides survival signals and growth and proangiogenic factors through contact-mediated and non-contact-mediated mechanisms. MM-associated macrophages in the tumor microenvironment potentially support tumor plasma cells. When activated by MM plasma cells and mesenchymal stromal cells, macrophages release growth factors, proteolytic enzymes, cytokines, and inflammatory mediators that enhance the growth and survival of these plasma cells. Tumor progression is promoted by MM-associated macrophages through angiogenesis, growth, and drug resistance. Evidence suggests that macrophages have a critical role in the biology and survival of patients with MM; thus, they may be a therapeutic target in MM patients. Blockage of protective signals on the surface of MM plasma cells results in macrophage-mediated killing of those cells. Targeted reprogramming of interactions within the tumor microenvironment holds great potential for treating MM patients.