User:Axe30

Hello! I am a student at McGill University.

Plan for the Laryngeal Papillomatosis article
For the Laryngeal papillomatosis page, I want to improve the signs and symptoms section and add a prognosis section.

If needed, I want to include information about the Derkay staging system and I want to search about secondary deficits (for example the relationship between gastroesophageal reflux disease and recurrent respiratory papillomatosis ). I also want to search the literature to provide reliable sources.

Signs and symptoms (working draft)
Affection of the larynx results in changes in voice quality. More specifically, hoarseness is observed. As a consequence of the narrowing of the laryngeal or tracheal parts of the airway, dyspnea (i.e shortness of breath), chronic cough and stridor (i.e. noisy breathing which can sound like a whistle or a snore), are noticed. As the disease progress, occurrence of secondary symptoms such as dysphagia, pneumonia, acute respiratory distress, failure to trive and recurrent upper respiratory infections can be diagnosed.

Adults
In adults, the most commonly reported symptoms of laryngeal papillomatosis is hoarseness.

or a strained or breathy voice. Size and placement of the tumors dictate the change in the person's voice. Breathing difficulties may occur but more commonly are found in children.

Children
Symptoms appear in a delayed trend in children.

In babies and small children, the signs and symptoms include a weak cry, trouble swallowing, noisy breathing, and chronic cough. Noisy breathing may be a stridor, which can sound like a whistle or a snore, and is a sign that the laryngeal or tracheal parts of the airway are narrowing.

Prognosis (working draft)
The evolution of Laryngeal Papillomatosis is highly unpredictable and is characterized by modulation of it's severity and variable rate of progression across individuals. While instances of total recovery are observed, the condition is often persistent and lesions can reappear even when treated. Factors that might affect the clinical course of the condition include : the HPV genotype, the age at onset, the elapsed time between the diagnostic and first treatment in addition to previous medical procedures. Other factors, albeit controversial, such as smoking or the presence gastroesophageal reflux might also play a role in the progression of the disease.

The papillomas can travel past the larynx and infect extralaryngeal sites. In more agressive cases, infection of the lungs can occur with progressive airway obstruction. Although rare (less than 1% of people with Laryngeal Papillomatosis), transformation from a benign form to a malignant form is also observed. Death can result from these complications (morbidity rate is around 1-2%).