User:Axe30/sandbox

Plan for the Laryngeal Papillomatosis article
For the Laryngeal papillomatosis page, I want to improve the signs and symptoms section and add a prognosis section.

If needed, I want to include information about the Derkay staging system and I want to search about secondary deficits (for example the relationship between gastroesophageal reflux disease and recurrent respiratory papillomatosis ). I also want to search the literature to provide reliable sources.

Signs and symptoms (working draft)
A common symptom of laryngeal papillomatosis is a perceptual change in voice quality. More specifically, hoarseness is observed. As a consequence of the narrowing of the laryngeal or tracheal parts of the airway, dyspnea (i.e shortness of breath), chronic cough and stridor (i.e. noisy breathing which can sound like a whistle or a snore), can be present. As the disease progresses, occurrence of secondary symptoms such as dysphagia, pneumonia, acute respiratory distress, failure to thrive and recurrent upper respiratory infections can be diagnosed. In children, symptoms are usually more severe and often misperceived as manifestations of other diseases such as asthma, croup or bronchitis. Therefore, diagnosis is usually delayed.

Prognosis (working draft)
The evolution of laryngeal papillomatosis is highly unpredictable and is characterized by modulation of its severity and variable rate of progression across individuals. While instances of total recovery are observed, the condition is often persistent and lesions can reappear even after treatment. Factors that might affect the clinical course of the condition include : the HPV genotype, the age at onset, the elapsed time between the diagnosis and first treatment in addition to previous medical procedures. Other factors, albeit controversial, such as smoking or the presence gastroesophageal reflux disease might also play a role in the progression of the disease.

The papillomas can travel past the larynx and infect extralaryngeal sites. In more aggressive cases, infection of the lungs can occur with progressive airway obstruction. Although rare (less than 1% of people with laryngeal papillomatosis), transformation from a benign form to a malignant form is also observed. Death can result from these complications (morbidity rate is around 1-2%).