User:AzulRover/Coiled coil/Shal613 Peer Review

General info
(provide username)
 * Whose work are you reviewing?


 * Link to draft you're reviewing:
 * Link to the current version of the article (if it exists):

Evaluate the drafted changes
(Compose a detailed peer review here, considering each of the key aspects listed above if it is relevant. Consider the guiding questions, and check out the examples of what feedback looks like.)

First peer review

 * 1) Consistency in Terminology:
 * 2) * In the sentence "Glycoprotein gp120 is closely associated to a trimer of gp41," it would be more grammatically accurate to use "associated with" instead of "associated to."
 * 3) Clarity in Sentence Structure:
 * 4) * The sentence "Upon binding of gp120 to the CD4 receptor and coreceptor, a number of conformational changes in the structure leads to the dissociation of gp120 and to the exposure of gp41 and at the same time to the anchoring of the gp41 N-terminal fusion peptide sequence into the host cell" is complex. Consider breaking it into more straightforward sentences for better readability.
 * 5) Precision in Expression:
 * 6) * The phrase "a number of conformational changes in the structure" could be enhanced by specifying the nature of these changes for a more precise description.

Second peer review

 * 1) Consistency in Tense:  Change "Recently, inhibitors derived from HR2 such as Fuzeon (DP178, T-20) bind to the HR1 region on gp41 have been developed"   to   "Recently, inhibitors derived from HR2, such as Fuzeon (DP178, T-20), that bind to the HR1 region on gp41 have been developed."
 * 2) Explicit Referencing:  Change "Chimeras of these HR1-derived peptides with GCN4 leucine zippers have been developed and have shown to be more active than Fuzeon, but these have not entered the clinic yet,"   To  "Chimeras of HR1-derived peptides with GCN4 leucine zippers have been developed and have shown greater activity than Fuzeon, but these chimeras have not entered the clinic yet."
 * 3) Cohesiveness in Structure:
 * 4) * The transition between discussing the HIV entry process and the subsequent information on molecular spacers could be smoother. Consider adding a sentence that provides a clear bridge between the two topics.
 * 5) Use of Pronouns:
 * 6) * Change "Because of their specific interaction coiled coils can be used as a ' tags' to stabilize or enforce a specific oligomerization state," To "Because of their specific interactions, coiled coils can be used as 'tags' to stabilize or enforce a specific oligomerization state."