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Polyomavirus Capsid Protein(VP1), also known as Major Capsid Protein VP1, is a viral RNA-dependent RNA polymerase ( RdRp), which is a minor component of the viral inner core. This protein, besides having common RdRp features, also contains large unique regions that might be responsible for the characteristic properties observed in the Reoviridae family (such as rotavirus).

Polyomaviruses have five to seven proteins, including three capsid proteins, VP1, VP2, and VP3, and two proteins, T and t, which are involved in replication of DNA.

VP1 is found in retrovirus such as Human polyomavirus (type JC)

HISTORY

Dr. Sarah Stewart and Dr. Bernice E. Eddy were the first ones to describe the polyoma virus. "Polyoma" is a word derived from the Greek roots “poly-”, meaning many or much, and “-oma”, meaning tumors. Until 2000 d.C, polyomaviruses were taxonomically classified as a genus in the family papovaviridae. With the publication of the Seventh Report of the International Committee on Taxonomy of Viruses, papovaviridae was split into two new families, papillomaviridae and polyomaviridae. Here we see some differences between them