User:Baflyer2/Ketotic hypoglycemia/Bibliography

You will be compiling your bibliography and creating an outline of the changes you will make in this sandbox.

Outline of proposed changes

 * Overall, need to reorganize flow of article: causes, signs/symptoms, diagnosis, natural history, treatment
 * Introduction
 * Include brief definition of ketosis, since this is missing
 * "It remains one of the most common causes of hypoglycemia in the age range" --> in what specific age range? I think this is trying to say "in children" --> double check reference
 * Should also briefly discuss that "ketotic hypoglycemia" encompasses both a physiological and pathological state
 * Physiologic KH:
 * Normal response to acute stressors such as infection, fever
 * Briefly review physiology (need for continuous fuel source for brain, in absence of available glycogen ---> fatty acid oxidation and ketosis)
 * Children tend to outgrow this with age
 * Then, pathologic KH:
 * Metabolic derangement caused by hormone deficiency, glycogen storage disorder
 * Some of what is included in the signs/symptoms section probably should be in the treatment section (e.g. treatment with saline/dextrose)
 * Ketotic hypoglycemia in glycogen storage disorders should probably be in the "Causes" section instead of the signs/symptoms section
 * Other causes: Silver-Russel syndrome
 * Diagnosis:
 * Include definitions: Christesen et al paper defines pathological IKH as beta-hydroxybutyrate > 1.0 mmol/L and blood glucose < 70 mg/dL
 * In absence of obvious triggers such as fasting, infection, chronic disease etc
 * Treatment:
 * Management for physiologic KH is treatment of the underlying cause
 * Management of pathologic KH:
 * POC glucometer
 * Corn starch vs G tube (in cases of severe KH)
 * IM glucagon, IV saline/dextrose (inpatient management)