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BZW2 is a protein encoded by the gene BZW2, also known as basic leucine zipper W2 domain-containing protein 2, MST017, MSTP017, HSPC028, 5MP1, and eIF5-mimic protein. The protein is a translation factor. Highly conserved orthologs can be found in vertebrates, invertebrates, fungus, and plants. Bacteria also contain the gene in a less-conserved format.

High protein expression can be found within the heart and placenta. At the cellular level, expression is highest in the plasma membrane and cytoplasm, with little to no expression within the organelles. It is listed to participate in cadherin binding, neural formation, and cell differentiation.

BZW2 expression has a direct relationship with rates and severity of numerous cancers, including colorectal cancer, muscle-invasive bladder cancer, lung adenocarcinoma, and osteosarcoma.

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