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Interactions with exogenous JSRV
There are 27 copies of the endogenous Jaagsiekte Retrovirus (enJSRV) that can be found in the sheep genome and some data suggests some of the sequences have been positively selected for in evolution. The expression of the enJSRV has the ability to inhibit the exogenous Jaagsiekte retorvirus due to the similarity between the genomic sequences where 5 out of the 27 copies show intact sequences found in all retroviruses. An example of this protection is seen in ovine endometrial epithelium where the high expression of enJSVR prevents exJSVR from entering the cells via blocking the common receptor to both, HYAL2.