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Biological activity
Some epidemiological studies have found a positive association between the consumption of foods containing kaempferol and a reduced risk of developing several disorders such as cancer and cardiovascular diseases. Numerous preclinical studies have shown kaempferol and some glycosides of kaempferol have a wide range of pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, cardioprotective, neuroprotective, antidiabetic, antiosteoporotic, estrogenic/antiestrogenic, anxiolytic, analgesic, and antiallergic activities (see review article).

Many glycosides of kaempferol, such as kaempferitrin and astragalin, have been isolated as natural products from plants. Kaempferol consumption in tea and broccoli has been associated with reduced risk of heart disease. A related compound, naringenin, may be present at the same time, such as in grapefruit.

Kaempferol gives the flowers of Acacia decurrens and Acacia longifolia their color. Antidepressant properties have been reported in tests on animals. ,

An eight-year study found the consumption of three flavonols (kaempferol, quercetin, and myricetin) correlated with a lower risk of pancreatic cancer among current smokers, but not nonsmokers and exsmokers.

Kaempferol consumption is also correlated with a reduced lung cancer incidence.

Kaempferol has demonstrated a wide range of potential anti-cancer and chemo-preventive properties in in vitro and in vivo pre-clinical studies. It has been shown to interrupt cell growth, limit angiogenesis, induce apoptosis, and reduce their available energy and ability to metastasize in various malignant cancer cells and animal models.

Kaempferol may be a potent prophylactic against NOX-mediated neurodegeneration.

Kaempferol has been found to inhibit the enzyme fatty acid amide hydrolase (FAAH). It was also demonstrated to act as agonist of PPARgamma, nuclear receptor that is current pharmacological target for the treatment of diabetes type 2.

A recent study showed that dietary kaempferol alleviates lung fibrosis in mouse experimental model.