User:Bcpham549/sandbox

First Draft: November 2nd Dihydrocodeine in both extended-release and immediate-release form are also sometimes used for maintenance treatment as an alternative to methadone or buprenorphine in some European countries.[66] Dihydrocodeine is a synthetic compound that works as an opioid agonist[67]. Dihydrocodeine, is used as either a mono-therapy or can be combine with other codeines for the management of pain. Dihydrocodeine, is often used as a second line treatment for pain management when other analgesic treatments are not adequately effective[68]. Alternatives to Dihydrocodeine should first be consider for the management of opiod addiction due to the lack of effective data suggesting its safety of use. A study on the death of opioid misusers shown an increased of 584 fatalities when Dihydrocodeine was used as either mono or comboination treater with other analgesics [69]. More data and research trials are needed before Dihydrocodeine should be consider as an intervention for the treatment of opiate addiction.

New propose revisions Dihydrocodeine in both extended-release and immediate-release form are also sometimes used for maintenance treatment as an alternative to methadone or buprenorphine in some European countries.[76] Dihydrocodeine is an synthetic compound and opioid agonist.[77] It may be used as a second line treatment.[78] There is a lack of effective data suggesting its safety of use with concerns of more deaths.[79]

Revision/Final Edits In order to address the lack of evidence and clinical trials for the efficacy of Dihydrocodeine, Robertson et al, proceeded with a randomized trial to answer weather or not it can be use in the management of opioid dependence. The Randomized trail study compared the efficacy of Dihydrocodeine versus Methadone use, for the maintenance treatment for opioid dependence. The conclusion of the trial was that Dihydrocodeine was equally as effective as Methadone. In another study Dihydrocodeine, show to increase mortality when used as either a mono-therapy or in combination with other analgesics. More effective data is needed to address the efficacy and safety concern fo the use of Dihydrocodeine in the treatment of opioid dependence. Bcpham549 (talk) 21:01, 20 November 2018 (UTC)

Sources: 1.https://ebmh.bmj.com/content/10/3/88 2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162662/