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UCSF Helen Diller Family Comprehensive Cancer Center is an NCI-designated_Cancer_Center, affiliated with the UCSF School of Medicine and the UCSF Medical Center. It is one of 69 cancer research institutions in the United States supported by the National Cancer Institute, and one of three in Northern California. The HDFCCC integrates basic and clinical science, patient care, and population science to address prevention and early detection of cancer as well as the quality of life following diagnosis and treatment.

HDFCCC is a member of the University of California Cancer Consortium, the National Comprehensive Cancer Network (NCCN) and Association of American Cancer Institutes. Cancer programs at UCSF have been continuously accredited since 1933 by the Commission on Cancer of the American College of Surgeons.

History
In 1948, the University of California at San Francisco (UCSF) established the Cancer Research Institute. In 1992,  UCSF  received  an  NCI planning  grant  to  develop  a Cancer Center. The Center received its NCI "Comprehensive" designation in 1999 and was renamed the UCSF Helen Diller Family Comprehensive Cancer Center in 2007 in honor of philanthropist Helen Diller.

Locations
Cancer care, research, and training programs are carried out across San Francisco at UCSF locations at Mission Bay in Potrero, Mount Zion in the Western Addition neighborhood, Parnassus near Golden Gate Park, Zuckerberg San Francisco General Hospital in the Mission neighborhood, and San Francisco Veterans Affairs Medical Center in the Richmond district.

In addition to individual lab space across UCSF campuses, there are cancer research facilities at Mount Zion and Mission Bay. The Helen Diller Family Cancer Research Building at Mission Bay was designed by Rafael Viñoly and opened in June 2009.

UCSF/Parnassus is the center for patient care in neurologic oncology; leukemia, lymphoma, and other hematopoietic malignancies; and bone marrow transplant. Mount Zion offers outpatient facilities for radiation oncology, breast care, infusion, pediatric dermatology, and support services. The Bakar Cancer Hospital opened on the Mission Bay campus in 2015 and has 70 adult beds and serves patients with orthopedic urologic, gynecologic, head and neck and gastrointestinal and colorectal cancers. The UCSF Benioff Children's Hospital at Mission Bay accommodates the Center's Pediatric Oncology Program. Groundbreaking for a new Precision Cancer Medicine Building at the Mission Bay campus began in 2017, with the facility scheduled to open to patients in 2019.

Ranking
In 2016, the center ranked first in California and sixth nationwide in National Cancer Institute research grants. In 2017 U.S. News & World Report "America’s Best Hospitals" survey ranked UCSF 10th for cancer care and Elsevier, a global scientific and medical publisher, ranked the HDFCCC among the world's top five institutions producing the most impactful and utilized research.

Notable Faculty

 * Alan Ashworth, a Fellow of the Royal Society and former director of the Institute of Cancer Research (ICR) and part of the team that discovered the BRCA2 gene in 1995, began leading the Center in 2015.
 * Frank McCormick, whose work targeted ways of treating cancer based on alterations in the Ras pathway, as well as other oncogenic drivers and tumor suppressors, led the HDFCCC from 1997 to 2014.
 * J. Michael Bishop and Harold Varmus won the Nobel Prize in 1989 for discovering cancer-causing oncogenes.
 * Elizabeth Blackburn won the Nobel Prize in 2009 for co-discovering telomerase, the enzyme that replenishes the telomere.
 * Peter Walter received the 2014 Albert Lasker Basic Medical Research Award for his discovery concerning the unfolded protein response.
 * Laura J. Esserman was noted in Time Magazine's 2016 list of the 100 most influential people in the world
 * Laura J. van 't Veer received the European Inventor Award in 2015 for her gene-based breast cancer test which resulted in the patented MammaPrint test to assess early stage breast cancer patients for risk of metastasis.
 * Allan Balmain was awarded a Fellow of the Royal Society in 2015 for his innovative use of mouse genetics.
 * Zena Werb was awarded the E.B. Wilson Medal by The American Society for Cell Biology in 2007.
 * Jeffrey Bluestone was appointed to the Blue Ribbon Panel of the Cancer Moonshot Initiative in 2015 and heads the new Parker Institute for Cancer Immunotherapy.