User:Begum0942/AS04

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The heightened immune response was caused by the MPL component in AS04 which increased NF-kB and cytokine production. The aluminum hydroxide component in AS04 made the response last for a longer period of time. This is the reason why the HPV-16/18 AS04-adjuvanted vaccine was shown to be more efficient compared to an aluminum salt-adjuvanted formulation with a higher level of antibodies found in the body.