User:Benjah-bmm27/lithiation-borylation

Lithiation–borylation is a reaction used in organic synthesis to create asymmetric carbon centres stereospecifically.


 * Lithiated carbamates (Hoppe) react with organoboron compounds (boranes or boronic esters), forming a carbon-boron bond R3C–BX2 (X = R or OR)
 * R2HC–OCb → R2LiC–OCb
 * R2LiC–OCb + ArBX2 → R2ArC–BX2 + (LiOCb)
 * OCb = carbamate, i.e. O–C(=O)–NR2
 * Boranes give one stereoisomer
 * Boronic esters give the other stereoisomer. Commonly used is RBpin, a pinacol ester of a boronic acid, RB(OH)2