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Cxorf26(Chromosome X Open Reading Frame 26) is a human gene found on the plus strand of the short arm of the X chromosome.The gene can be found under the aliases MGC874 and the homolog version in mice of 2610026G26Rik. The function of the gene is mainly unknown, but the polysaccharide biosynthesis domain that spans a major portion of the protein offers particular insights into its possible function within the human genome.

Location
Cxorf26 is found on the plus strand of the short arm of the X chromosome, specifically on the gene locus Xq13.3 spanning the genomic chromosome region from bases 75,393,420-75,397,740. . The primary mRNA transcript sequence has 1214 base pairs and can be found on NCBI with the accession number NM_106500.3. . Cxorf26 codes for the UPF0368 protein, which is composed of 233 amino acids with the NCBI accession number NP_057584.2. and has a predicted mass of 26,057 Da. .

The locus where Cxorf26 is located, Xq13.3, has known associations to causing mental retardation effects. . The third gene located upstream of Cxorf26 is ATRX, which encodes for an ATPase/helicase domain, and when mutated causes an X-linked mental retardation syndrome along with alpha thalassemia syndrome; both are known to cause changes in the DNA methylation patterns. Furthermore, the third gene downstream of CXorf26, ZDHHC15, which when mutated, causes mental retardation X-linked type 91. One noteworthy gene located nearby is Xist, which plays a role in the inactivation process of the X chromosome. X inactivation relates to Cxorf26, and is discussed below in the relevant research section.