User:Bhnson1/Isoleucine/Jiewlord Peer Review

General info

 * Whose work are you reviewing?

Bhnson1


 * Link to draft you're reviewing
 * https://en.wikipedia.org/wiki/User:Bhnson1/Isoleucine?preload=Template%3ADashboard.wikiedu.org_draft_template


 * Link to the current version of the article (if it exists)
 * Isoleucine

Evaluate the drafted changes
Lead

The lead was not touched.

So far, the lead gives a general overview of what isoleucine is. The lead so far is pretty concise and sticks to the point without going too in depth with the topic.

Biosynthesis

The biosynthesis subsection under Metabolism section was a good improvement. It outlined what sort of organism is isoleucine an essential nutrient for.


 * 1) Acetolactate synthase, you can remove the also known part in parentheses. If someone reading this article was curious to what acetolactate synthase was, they would click on the hyperlink for that.
 * 2) Acetohydroxy acid isomeroreductase: Unless you are going to create a whole new article on this topic, I suggest you remove the hyperlink for acetohydroxy acid isomeroreductase.

Catabolism

No changes added to this section. This section is fine the way it is.

Insulin resistance

No changes added to this section. Is it necessary to include the mice experiment under this section? It isn't necessary, in my opinion to have the couple sentences that described this experiment in the isoleucine article.

Function and requirement

Under this section, it would be in your best interest to explain why isoleucine is an essential component of many proteins and how it is necessary for the formation of fetal hemoglobin. Although you included a link to the source of this article, it is in your best interest to explain this statement. The revision that you have added is well written, concise, and clear.

Nutritional sources

This part was well written, in my opinion. However, I think it would be good idea to separate this section into two paragraphs: one to explain ingestion of isoleucine from proteins, and a second paragraph that lists the foods that have the high amounts of isoleucine in it.

Isomer

It was a wise decision to remove that redundant table that was in the original article. You should still discuss D-isoleucine and L-isoleucine and how the differing molecular geometry of the two isoleucine molecules have different roles in biochemistry. This means that you can also include the original molecular structures from the original article to your revision.

Synthesis and discovery

What you have here, so far is a great addition compared to what the original article had. However, the synthesis section should be separate from the discovery (History). This separation was lacking in the original article because it did not go in depth with the history of the discovery of isoleucine. In your revisions, it would be a good idea to have these two as separate sections. otherwise, this will make the revised article unorganized.

You should include the synthesis pathways that you have mentioned in the external link section below.

External link and sources

I looked at these links and I am assuming you are trying to show the isoleucine degradation and biosynthesis pathways, but have no idea how to incorporate this into your wikipedia article. You might want to use a tool such as ChemDraw, or BIOVIA to draw out these mechanism pathways and have this under the synthesis section. Add the citation for these new synthesis pathways in your revision.

On the other hand, the other links that you have included are relevant to the content that you have included/revised.

Images

No images were added to this revision. I suggest to include an image of the synthesis pathway under the synthesis section.