User:Bilguudei Naranbaatar

First Draft
Full edit on WIkipedia

Bring in 3 hard copies to class, with changes highlighted (some indication)

Images/Diagrams
Go to wikipathways.org to make pathway diagrams

Upload images to wikimedia commons

Can make images from protein database files

Use whatever drawing software you want

Chemical structures cant have a copyright, neither do general well known and established pathways and mechanisms

wikiproject chemistry for drawing chemicals rules

Chemdraw: File, apply document settings from ACS Document 1996

Try to save as svg, if not png

Proposal
The changes all belong to 3 of the already present subheaders, Structure, Interactions, and Function. The structure section will involve a description of the various domains present in the caspase 1 protein as well as the caspase 1 interacting proteins. The important structures in caspase 1 and its interacting proteins are Caspase recruitment domains (CARDs) and Pyrin domains (PYDs).

These structures then become very important going into the next section, interactions. Here, I will discuss how the inflammasome assembles through interactions of these domains, with PYD-PYD interactions allowing a sensor protein to bind to an adaptor protein, and CARD-CARD interactions which allows the inflammasome to attach to the caspase. While this is true for many types of inflammasomes, it is not true for all, as some sensors bind directly to caspase-1, through other interactions. The CARD domains also play an important role in inhibition, where several CARD only proteins (COPs) act to repress caspase functions.

Finally, I will provide detailed mechanisms for the activation of caspase 1 by the inflammasome formation, the cleavage of the IL-1beta and IL-18 precursors into mature cytokines, the cleavage of gasdermin D to induce pyroptosis, and the inhibition of caspase by the COPs. I will also discuss some of the downstream effects of the mature cytokines, the various sensors that are possible in the activation of caspase 1, as well a contested topic: whether or not pyroptosis is necessary for secretion of the mature cytokines.

Note: not all papers listed in the references will be necessary for these changes, but certainly more will be used than the 3 currently cited as of now.

Please let me know what other changes I could add, or any changes in structure and organization you might suggest. Thanks!

=== References       ===