User:BinkyUrban/Jane Endicott

Professor Jane Endicott
=== Professor of Cancer Structural Biology, Newcastle University Faculty of Medical Sciences and Emeritus Fellow, St Cross College, University of Oxford. ===

Professor Jane Endicott has been Professor of Cancer Structural Biology at Newcastle University's Faculty of Medical Sciences and a member of the Cancer Research UK Newcastle Drug Discovery Unit (CRUK Newcastle DDU) since October 2011. She is also a member of the Newcastle University Cancer Leads Group and the Newcastle University Centre for Cancer Fellowships Steering Group.

Cell cycle structural biology and phosphorylation transcription are among Professor Endicott's areas of expertise. Her group conducts studies exploring the structure-function relationships of protein complexes involved in transcription and other cell cycle processes in eukaryotes. It also inputs structural biology expertise into CRUK Newcastle DDU projects.

After studying Biochemistry at Corpus Christi College, the University of Oxford, Professor Endicott completed her PhD at the Ontario Cancer Institute, as part of the laboratory team of Victor Ling. In 1991, she joined the laboratories of Professors Paul Nurse and Louise Johnson at the University of Oxford, in her capacity as a Junior Research Fellow of the National Cancer Institute of Canada, to conduct research into cyclin-dependent protein kinases (CDKs). She was awarded a Royal Society University Research Fellowship in 1995, and has a Lecturership at Trinity College, University of Oxford.

Professor Endicott is listed as a member of the Editorial Board for the Biochemical Journal, Portland Press.

PubMed lists over 65 publication listings for Professor Endicott, including:


 * Structural insights into the functional diversity of the CDK-cyclin family. Wood DJ, Endicott JA. Open Biol. 2018 Sep;8(9):180112. doi: 10.1098/rsob.180112. PMID: 30185601 Free PMC article. Review.


 * CDK1 structures reveal conserved and unique features of the essential cell cycle CDK. Brown NR, Korolchuk S, Martin MP, Stanley WA, Moukhametzianov R, Noble MEM, Endicott JA. Nat Commun. 2015 Apr 13;6:6769. doi: 10.1038/ncomms7769. PMID: 25864384 Free PMC article.


 * Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4. Myers SM, Miller DC, Molyneux L, Arasta M, Bawn RH, Blackburn TJ, Cook SJ, Edwards N, Endicott JA, Golding BT, Griffin RJ, Hammonds T, Hardcastle IR, Harnor SJ, Heptinstall AB, Lochhead PA, Martin MP, Martin NC, Newell DR, Owen PJ, Pang LC, Reuillon T, Rigoreau LJM, Thomas HD, Tucker JA, Wang LZ, Wong AC, Noble MEM, Wedge SR, Cano C. Eur J Med Chem. 2019 Sep 15;178:530-543. doi: 10.1016/j.ejmech.2019.05.057. Epub 2019 May 25. PMID: 31212132


 * Structure-based discovery of cyclin-dependent protein kinase inhibitors. Martin MP, Endicott JA, Noble MEM. Essays Biochem. 2017 Nov 8;61(5):439-452. doi: 10.1042/EBC20170040. Print 2017 Nov 8. PMID: 29118092 Free PMC article. Review.


 * Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition. Wood DJ, Korolchuk S, Tatum NJ, Wang LZ, Endicott JA, Noble MEM, Martin MP. Cell Chem Biol. 2019 Jan 17;26(1):121-130.e5. doi: 10.1016/j.chembiol.2018.10.015. Epub 2018 Nov 21. PMID: 30472117 Free PMC article.


 * Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach. Miller DC, Martin MP, Adhikari S, Brennan A, Endicott JA, Golding BT, Hardcastle IR, Heptinstall A, Hobson S, Jennings C, Molyneux L, Ng Y, Wedge SR, Noble MEM, Cano C. Org Biomol Chem. 2018 Mar 14;16(11):1843-1850. doi: 10.1039/c8ob00099a. PMID: 29469144 Free PMC article.
 * Identification and Characterization of an Irreversible Inhibitor of CDK2. Anscombe E, Meschini E, Mora-Vidal R, Martin MP, Staunton D, Geitmann M, Danielson UH, Stanley WA, Wang LZ, Reuillon T, Golding BT, Cano C, Newell DR, Noble ME, Wedge SR, Endicott JA, Griffin RJ. Chem Biol. 2015 Sep 17;22(9):1159-64. doi: 10.1016/j.chembiol.2015.07.018. Epub 2015 Aug 27. PMID: 26320860 Free PMC article.


 * Cyclin-dependent kinase inhibitors. Fischer PM, Endicott J, Meijer L. Prog Cell Cycle Res. 2003;5:235-48. PMID: 14593718 Review.
 * Chatterboxes: the structural and functional diversity of cyclins. Tatum NJ, Endicott JA. Semin Cell Dev Biol. 2020 May 12:S1084-9521(19)30237-X. doi: 10.1016/j.semcdb.2020.04.021. Online ahead of print. PMID: 32414682 Review.


 * Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System. Hallett ST, Pastok MW, Morgan RML, Wittner A, Blundell KLIM, Felletar I, Wedge SR, Prodromou C, Noble MEM, Pearl LH, Endicott JA. Cell Rep. 2017 Oct 31;21(5):1386-1398. doi: 10.1016/j.celrep.2017.10.042. PMID: 29091774 Free PMC article.

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