User:BioRox333/sandbox

Diet’s interaction with the IGF-1 pathway [edit]
Research into the interaction between diet and the insulin/IGF-1 pathway has shown that sugar intake is negatively correlated with DAF-16 activity and longevity. One study found that glucose ingestion reduced the rate of dauer formation and suppressed the lifespan-extension effect of DAF-2 mutants to resemble that of wild type C. elegans. This finding suggests that DAF-16 mediated gene expression associated with longevity is suppressed by glucose ingestion. Wild type C. elegans fed a diet that included 2% glucose showed reduced daf-16 activity and lifespan was shortened by 20% compared to worms fed on glucose-free media. These findings raise the possibility that a low-sugar diet might have beneficial effects on life span in higher organisms.