User:Biochemistryfan/Alkylphosphocholine

Analogs of alkylphosphocholines were previously synthesized and shown to have applications in

both diagnostic cancer imaging and cancer therapy through in vivo and in vitro experiments. The

alkylphosphocoline analog CLR1404 was observed to be selectively absorbed by tumor cells in

both human patients with advanced metastatic cancer and mouse models through both PET

imaging with the radioactive isotope Iodine-124 as well as through SPECT imaging with the

therapeutic radioisotope Iodine-131. One of the causes for this selective uptake of CLR1404 was

hypothesized to be due to interactions between the analog and lipid rafts of the cancer cell

membrane as treatment with the compound Filipin III, which disturbs lipid rafts, resulted in less

uptake of the alkylphosphocoline analog. (1st reference)

Through in vitro studies, Alkylphosphocolines were observed to impede cell division of human

RPE (retinal pigment epithelium) cells. This has therapeutic implications on the treatment of

Proliferative Vitreoretinopathy, as this condition can lead to retinal detachment through the

abnormal growth and contraction of retinal membranes with RPE cells being significant in

facilitating this process. It was experimentally demonstrated that Alkylphosphocolines are able to

decrease the activity of Protein Kinase C in human RGE cells in vitro, which is one hypothesized

way that it is able to impede cell division of human RPE cells. (2nd reference)

References: https://www.science.org/doi/10.1126/scitranslmed.3007646

https://iovs.arvojournals.org/article.aspx?articleid=2200230

^^Add those to preexisting reference list