User:Biochemstudent96/CDKAL1/Hgarby Peer Review

Peer review
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General info

 * Peer Review for Urba/Biochemstudent96
 * User:Biochemstudent96/CDKAL1
 * Reviewed by Helen User:Hgarby

Lead evaluation
It's good that you established the gene vs protein distinction, I would make sure to include that this is found in humans. Maybe bring up the type 2 diabetes association alongside the function. My understanding is that its role in tRNA modification is relatively established. Including the diabetes relevance and currently understood function immediately gives the lead "here's what this is, what it does, and why it's relevant and studied".

Content evaluation
I found an article from January of this year supporting CDKAL1's role in tRNA modifications. doi:10.1038/s41467-019-14004-5 "Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification." I think that it is inaccurate to state that we don't know the function, perhaps instead indicate that the function is not fully understood or that its mechanism is not understood. If there are any papers describing the structure of the CDKAL1 protein then I would add a section describing them, particularly if any sulfur iron clusters as those are particularly relevant to methylthiotransferases. The health implication content was good!

Tone and balance evaluation
The content is neutral and does not misrepresent findings or mislead the reader

Sources and references evaluation
The sources are credible and all links work. Source 3 is not reading the date correctly so you may have to manually enter it

Organization evaluation
The content is well written but small tweaks could make it more precise. "Due to this involvement" might be changed to "Due to this presence". Perhaps also cut words like "also".

Be careful of tense, try to keep any facts present tense. i.e. "is attributed to" rather than "was attributed to", unless that fact no longer stands

Images and media evaluation
Make sure to include the gene information box from the original page, but other than that I do like the figure selected. I'm not entirely clear on the rules for using figures from papers so you may want to check in on those guidelines if you have not already.

Overall evaluation
Content-wise this is a huge improvement over the previous article. With a bit of structural information, clarification on function, and small organizational tweaks it will be a very good improvement on the existing page.